Results 181 to 190 of about 475,354 (308)

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

Isolated Pleural Effusion as Presentation of a Large B‐Cell Lymphoma: A Case Report and Diagnostic Considerations

Journal of Clinical Laboratory Analysis, EarlyView.
A 79‐year‐old man presented with massive pleural effusion in which cytological examination revealed lymphoma cells without evidence of a solid tumor mass. Negative EBV in situ hybridization and negative HHV8 and HIV testing, combined with flow cytometric immunophenotyping and molecular findings, supported a diagnosis of fluid overload–associated large ...
Van Vlierberghe Magalie, Dewaide Rosina, Michaux Lucienne, Develter Wim, Van Aelst Sophie, Claerhout Helena   +5 more
wiley   +1 more source

Association Between Multi‐Laboratory Parameters Pre‐ and Post‐Treatment and Pathological Features and Their Values in Clinical Decision in Primary Hepatic Carcinoma

Journal of Clinical Laboratory Analysis, EarlyView.
Primary hepatic cancer (PHC), especially hepatocellular carcinoma (HCC), is still a significant burden worldwide. The efficacy of diagnosis, treatment response monitoring, and prognostication using laboratory biomarkers is still a challenge. This study analyzed multi‐laboratory parameters pre‐ and post‐treatment and their associations with clinical and
Xiaowei Chi, Weifang Liu, Zihan Liu, Jie Liu   +3 more
wiley   +1 more source

Study of Risk Factors and Image Findings of Isolated Abdominal Incidentally Detected Aortic Dissection

Journal of Clinical Ultrasound, Volume 53, Issue 3, Page 429-435, March/April 2025.
We detect the risk factors and image characteristics of incidentally detected IAAD. Independent risk factors of IAAD included fatty liver and smoking. In the ultrasound findings of IAAD, an intimal flap was frequently observed. In the CT scan, displacement of intimal calcifications was frequently observed. For suspected IAAD, the abdominal aorta should
Hiromasa Tsubouchi, Hidenori Onishi, Koji Maeno, Masaya Nakagaichi, Ikue Tsukushi, Youichi Kitano, Yoshitaka Makino, Hiroyuki Hayashi, Hidekazu Terasawa, Hiroko Kabuto, Toshihiro Misawa, Taku Sanada, Azusa Hisada, Kazuo Notsumata, Kazuhiro Okafuji, Osamu Yamamura   +15 more
wiley   +1 more source

[A leukocyte virus in human hepatitis].

Voprosy virusologii, 1971
A K, Shubladze, I F, Barinskiĭ, I V, Dement'ev, B V, Gushchin, A F, Bocharov   +4 more
openaire   +1 more source

Student Anxiety and Stress Related to Needlestick/Sharps Injuries in Dental Clinics

Journal of Dental Education, EarlyView.
ABSTRACT Purpose/Objective This study explored how the threat of needlestick/sharps injuries affects stress and anxiety among dental, dental hygiene, and dental assisting students in accredited US programs. It also aimed to identify contributing factors and assess potential educational interventions.
Lindsey C. Billing, Marisa A. Cornewell
wiley   +1 more source

The Expanding Role of Companion Diagnostics in Infectious Diseases: Lessons From Abacavir and Human Immunodeficiency Virus Care

iLABMED, EarlyView.
Yi‐Wei Tang, Eric von Hofe
wiley   +1 more source

Trends in hospitalizations for vaccine‐preventable diseases in the United States from 2014 to 2024

Journal of Hospital Medicine, EarlyView.
Abstract Background and Objectives Vaccination rates have declined in recent years, resulting in outbreaks of vaccine‐preventable diseases (VPDs) among children. We aimed to evaluate VPD hospitalization rates from 2014 to 2024 and to report associated trends in outcomes including intensive care utilization, mortality, readmissions, and costs.
Nathan M. Money, Erin Sullivan, Hannah Rector, Corrie E. McDaniel, Jessica L. Markham, Mersine A. Bryan   +5 more
wiley   +1 more source