Results 251 to 260 of about 13,757,225 (358)

A serum exosomal microRNA‐based artificial intelligence diagnostic model for highly accurate detection of hepatocellular carcinoma

open access: yes
Cancer Communications, EarlyView.
Jin‐Seong Hwang   +21 more
wiley   +1 more source

Tislelizumab: Structural Innovations and Expanding Clinical Horizons in Next‐Generation PD‐1 Immunotherapy

open access: yesChronic Diseases and Translational Medicine, EarlyView.
The interaction of tislelizumab with PD‐1/PD‐L1 in the tumor microenvironment. Tislelizumab targets PD‐1 on T cells, blocking its interaction with PD‐L1 on tumor cells. This action is facilitated by a modified F(ab) region that limits Fc‐γ receptor binding, thereby enhancing the antitumor immune response. ABSTRACT Tislelizumab is a next‐generation PD‐1
Thy T. Nguyen   +4 more
wiley   +1 more source

Immunohistochemical Profiling of Immune Checkpoints in Chronic Hepatitis B Liver Tissue. [PDF]

open access: yesPathogens
Panão-Costa J   +6 more
europepmc   +1 more source

Asymmetric Total Synthesis of (−)‐Glycybridin B, a Pharmacophore Screened Candidate for Tubulin Binding

open access: yesChemistry – A European Journal, EarlyView.
Discovery and first total synthesis of (−)‐glycybridin B via a five‐step route utilizing a key chalcone intermediate. Initially identified through a pharmacophore screening as a potential tubulin binder, this natural product serves as a tool compound to explore structure‐activity relationships related to microtubule targeting and anticancer potential ...
Alice Maiocchi   +14 more
wiley   +1 more source

Role of Common Fractalkine Receptor Variants with Chronic Hepatitis B Patients in Tunisia. [PDF]

open access: yesViruses
Ben Dhifallah I   +11 more
europepmc   +1 more source

Harnessing Viral Proteases for Cellular and Molecular Engineering

open access: yesChemistry–Methods, EarlyView.
Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui   +2 more
wiley   +1 more source

Eliminating perinatal transmission of hepatitis B virus: it is time for action

open access: yesJournal of the International AIDS Society
Rania A. Tohme   +4 more
doaj   +1 more source

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