Results 261 to 270 of about 13,757,225 (358)

Identification of low-molecular compounds that inhibit envelope formation of hepatitis B virus. [PDF]

Sci Rep
Sato K, Inoue J, Ninomiya M, Sano A, Tsuruoka M, Onuki M, Sawahashi S, Ouchi K, Doi K, Watanabe K, Masamune A.   +10 more
europepmc   +1 more source

Pharmacokinetics, Safety, and Skin Irritation and Sensitization Potential of Clascoterone Cream in Early‐Phase Clinical Study Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano, Milko Massimiliano Radicioni, Gerhard Garhöfer, Martina Cartwright, Markus Müller, Iris Kopeloff, Luigi Moro, Nicholas Squittieri, Alessandro Mazzetti   +8 more
wiley   +1 more source

Global Systematic Review of the Measurement of Stigma Associated With People Living With Hepatitis B or Hepatitis C Viruses. [PDF]

J Viral Hepat
Green F, Simmons R, Leeman D, Desai M, Hibbert M.   +4 more
europepmc   +1 more source

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Food Effect of Bexicaserin in Healthy Participants: A First‐in‐Human Randomized, Double‐Blind, Placebo‐Controlled Single Ascending Dose Escalation Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective 5‐hydroxytryptamine 2C (5‐HT2C) superagonist in development for the treatment of seizures in developmental and epileptic encephalopathies (DEEs). This double‐blind, placebo‐controlled, single ascending dose (SAD) Phase 1 study aimed to assess the safety, tolerability, and pharmacokinetic (PK) and ...
Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R Srinivas, Randall Kaye   +6 more
wiley   +1 more source

Relationship of hepatitis B antigen in cirrhosis and hepatoma in Thailand. An etiological significance.

, 1975
T Chainuvati, Vikit Viranuvatti, D Pongpipat   +2 more
openalex  

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

Molecular characteristics of hepatitis B virus among students and pregnant women in Chad. [PDF]

BMC Infect Dis
Debsikréo N, Leye N, Lo G, Dehainsala M, Debsikréo O, Diaw NA, Ba D, Diagne D, Souare A, Diouf ND, Kouadio NKN, Otchere ID, Moussa AM, Toure-Kane NC, Lunel-Fabiani F.   +14 more
europepmc   +1 more source

Investigating the mechanisms of capsicum in age‐related hearing loss: Based on network pharmacology

Eye &ENT Research, EarlyView.
Abstract Background To explore the material basis and action mechanism of the chemical component gene of pepper on presbycusis, and to provide a reference for the traditional Chinese medicine treatment of age‐related hearing loss (ARHL). Methods The chemical composition and action targets of traditional Chinese medicine flavor of pepper were searched ...
Yan Wang, Xiaoyu Song, Fengxin Yang, Huhuifen He, Kun Zhao, Jingjing Qiu, Limei Cui, Qiang Zhang, Limei Liu, Yan Sun   +9 more
wiley   +1 more source

Hepatitis B Virus Variants and Cytokine Patterns in Acute Liver Failure and Transplant-Free Survival. [PDF]

Liver Int
Patel NH, Chen AY, Osiowy C, Durkalski Mauldin V, Lee WM, Coffin CS, Karvellas CJ, US Acute Liver Failure Study Group.   +7 more
europepmc   +1 more source