Results 221 to 230 of about 184,721 (306)

Antithrombin: Deficiency, Diversity, and the Future of Diagnostics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Our healthcare system provides reactive sick‐care, treating patients after symptoms have appeared by prescription of generic and often suboptimal therapy. This strategy brings along high costs and high pressure which is not sustainable.
Mirjam Kruijt, Christa M. Cobbaert, L. Renee Ruhaak   +2 more
wiley   +1 more source

Triple autoimmune overlap syndrome of the liver: a rare case of concomitant PBC, PSC, and AIH. [PDF]

Future Sci OA
Hassen H, Dahmani W, Bedoui G, Sakly S, Souilem E, Ghdiri Y, Jaziri H, Ben Slema A, Brahem A, Elleuch N, Ksiaa M.   +10 more
europepmc   +1 more source

Preoperative VEGFR‐TKI Plus ICI Therapy Facilitates 3D‐Guided Cytoreductive Nephron‐Sparing Surgical Feasibility and Immune Remodeling in Advanced Renal Cell Carcinoma

Med Research, EarlyView.
Preoperative VEGFR‐TKI plus ICI therapy in advanced ccRCC normalizes tumor vasculature, enhances CD8⁺ T/B cell infiltration, and promotes TLS maturation, leading to profound tumor microenvironment remodeling. These immunologic changes improve the feasibility of 3D reconstruction‐guided robotic cytoreductive nephron‐sparing surgery, resulting in reduced
Wenhao Xu, Aihetaimujiang Anwaier, Qintao Ge, Siqi Zhou, Xi Tian, Shuxuan Zhu, Guohai Shi, Yu Zhu, Dingwei Ye, Mierxiati Abudurexiti, Hailiang Zhang   +10 more
wiley   +1 more source

Short-term prednisolone for inducing seroconversion from hepatitis B e antigen to antibody along with clinical improvement in patients with chronic active hapatitis type B.

, 1987
Hiromitsu Kumada, Kenji Ikeda, Akira Yoshida, Sachiko SETO, Toshiyasu TSUKADA, Mineo Kojima, Hiroshi Suzuki, Makoto Mayumi   +7 more
openalex   +2 more sources

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Update on Hepatitis E Virus Infection 2025: Insights From an International Symposium. [PDF]

Liver Int
Buchardt L, Thi VLD, Johne R, Ziersch M, Harms D, Hofmann J, Dinkelborg K, Klöhn M, Choi M, Kurreck J, Wedemeyer H, Todt D.   +11 more
europepmc   +1 more source

Detection of serum HCV antibodies in Non A, Non B hepatitis, and correlation among the JCC.2 antibody and these pathological findings.

, 1993
Mitsuhiko Moriyama, Junko MORIYAMA, Atuso SHIODA, Fumihiko Komine, Takashi Motohashi, Kazutomo Suzuki, Shuichi Amaki, Naohide Tanaka, Hitoshi Ohkubo, Hideo Ishizuka, Yasuyuki Arakawa, Yutaka Matsuo, Keiichi Hayashi, Nakanobu Hayashi, K Suzuki, Toshikazu Uchida, Toshio Shikata   +16 more
openalex   +2 more sources

Genome‐wide analysis of somatic noncoding mutation patterns and mitochondrial heteroplasmic shift in type B1 and B2 thymomas

The Journal of Pathology, EarlyView.
Abstract Type B1 and B2 thymomas are lymphocyte‐rich malignant tumours with few somatic mutations in protein‐coding regions of the nuclear genome; nonetheless, noncoding regions remain uncharacterized. Here, we developed a method to isolate pure thymoma cells from lymphocyte‐rich tissues, and then performed genome‐wide deep sequencing. The total number
Kohei Fujikura, Isabel Correa, Susanne Heck, Kaoru Watanabe, Juliet King, Emma McLean, Susan Ndagire, Yoshihisa Takahashi, Masahiko Kuroda, Andrea Bille, Daisuke Nonaka   +10 more
wiley   +1 more source

Challenges in the Diagnosis of Autoimmune Hepatitis in Patients With Chronic Viral Hepatitis C: A Case Series and Review of the Literature. [PDF]

Cureus
Malakar S, Kumar S, Jangra R, Agarwal M, Parwar A, Kohli KP, Mishra S, Bhardwaj A, Kumar A, Singh A, Yadav DK, Tiwari A, Gandhi A, Shukla G, Rungta S.   +14 more
europepmc   +1 more source

IKAROS Associated Immunodeficiency and Thrombotic Thrombocytopenic Purpura

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pathogenic variants in IKZF1 (IKAROS) are linked to immunodeficiency, malignancy, and immune dysregulation. We describe a family with a rare IKZF1 variant presenting with humoral immunodeficiency and thrombotic thrombocytopenic purpura (TTP). A non‐consanguineous family was clinically monitored; clinical, immunological, and genetic data (exome
Ilia Spivak, Daniella Magen, Karin Weiss, Tamar Paperna, Suhair Hanna, Amos Etzioni, Adi Miller‐Barmak, Yonatan Butbul Aviel   +7 more
wiley   +1 more source