Results 31 to 40 of about 192,633 (312)
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Hepatitis B virus antibody prevalence in anaesthetists [PDF]
Canadian Anaesthetists’ Society Journal, 1984 The prevalence of antibodies to hepatitis B virus (anti HBs or anti HBc) was 16.9 per cent in a group of anaesthetists, compared to 3.7 per cent in volunteer blood donors and 5.6 per cent of patients without hepatic infections. Professional risk factors such as treating a hepatitis B patient or working in a hospital laboratory, haemodialysis, an ...
M A, Chernesky, R A, Browne, P, Rondi
openaire +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan +5 more
wiley +1 more source
Hepatitis B Vaccination in Persons with Isolated Hepatitis B Core Antibodies [PDF]
Clinical Infectious Diseases, 1999 SIR-Silva et al. [1] suggested that in the population they have studied, isolated antibodies to hepatitis B core antigen (anti-HBc) are false-positive results. Their arguments are based on the facts that only five persons among the 133 investigated had hepatitis B virus (HBV) DNA detected in their serum and that most had a primary response to HBV ...
Brian J. McMahon, Alan J. Parkinson
openaire +3 more sources
PREVALENCE OF HEPATITIS A IN B AMONG BLOOD DONORS WITH HISTORY OF JAUNDICE
Zdravniški Vestnik, 2004 Background. Preventing transmission of infectious disease through blood transfusion presents one of the greatest challenges of transfusion medicine.
Božislava Majcen Vivod +1 more
doaj
Medical Journal of Babylon, 2020 Background: Recurrent abortion is a globally common problem. Many factors play a crucial role in the pathogenesis of abortion such as antinuclear antibodies (ANA), antibrucella antibodies and hepatitis B surface antigen (HBsAg).
Nabaz Fisal Shakir Agha
doaj +1 more source
Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez +10 more
wiley +1 more source
Impact of Hepatitis B Surface and Core Antibody Levels on Hepatitis B Virus Reactivation
Biological and Pharmaceutical Bulletin, 2023 Abstract Hepatitis B virus reactivation (HBV-R) is a serious concern during cancer chemotherapy in patients with resolved HBV infection. We examined the levels of HBV surface (HBsAb) and core antibodies (HBcAb) to assess the incidence of HBV-R in patients with solid and hematopoietic cancers.
Ohkubo, Maki +5 more
openaire +2 more sources