Results 121 to 130 of about 420,842 (369)

A Transcriptome‐Wide Mendelian Randomization Study in Isolated Human Immune Cells Highlights Risk Genes Involved in Viral Infections and Potential Drug Repurposing Opportunities for Schizophrenia

open access: yesAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Schizophrenia is a neurodevelopmental psychiatric disorder characterized by symptoms of psychosis, thought disorder, and flattened affect. Immune mechanisms are associated with schizophrenia, though the precise nature of this relationship (causal, correlated, consequential) and the mechanisms involved are not fully understood.
David Stacey   +6 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

open access: yes, 2022
Hepatology, EarlyView.
Robert J. Fontana   +6 more
wiley   +1 more source

Immunosuppression for liver transplantation in HCV-infected patients: Mechanism-based principles [PDF]

open access: yes, 2005
We retrospectively analyzed 42 hepatitis C virus (HCV)-infected patients who underwent cadaveric liver transplantation under two strategies of immunosuppression: (1) daily tacrolimus (TAC) throughout and an initial cycle of high-dose prednisone (PRED ...
Bass, DC   +10 more
core   +1 more source

Host Components in Hepatitis B Antigen

open access: yesJournal of General Virology, 1975
Purified [125I]-labelled 20 to 25 nm hepatitis B antigen particles were found to give low affinity immunoprecipitation reactions with antisera to several normal serum components, which were immunologically distinct from the reaction due to the classical hepatitis B antigen surface determinant.
openaire   +4 more sources

Application of humanized mice in the safety experiments of antibody drugs

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun   +9 more
wiley   +1 more source

Use of existing data for public health planning: a study of the prevalence of hepatitis B surface antigen and core antibody in Al Ain Medical District, United Arab Emirates

open access: yesBulletin of the World Health Organization, 2000
INTRODUCTION: Hepatitis B is of major public health importance. Accurate information on its occurrence, with particular reference to the prevalence of immunity and chronic infection (marked by the presence of hepatitis B core antibody and surface antigen,
A. Al-Owais   +5 more
doaj  

Genomic modeling of hepatitis B virus integration frequency in the human genome.

open access: yesPLoS ONE, 2019
Hepatitis B infection is a world-wide public health burden causing serious liver complications. Previous studies suggest that hepatitis B integration into the human genome plays a crucial role in triggering oncogenic process and may also constitutively ...
Ondrej Podlaha   +7 more
doaj   +1 more source

Seroprevalence of viral hepatitis in riverine communities from the Western Region of the Brazilian Amazon Basin

open access: yesMemorias do Instituto Oswaldo Cruz, 2001
The western region of the Brazilian Amazon Basin has long been shown to be a highly endemic area for hepatitis B and hepatitis D viruses. Data concerning the prevalence of hepatitis C and E viruses in this region are still scarce.
VS de Paula   +3 more
doaj   +1 more source

Identification of bioactive compounds and molecular targets of Fuke Huahuang formulation to treat vaginitis

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Fuke Huahuang formulation (FHF) is used to treat vaginitis, and it exerts a promising anti‐inflammatory effect in clinical use. However, the detailed components and mechanisms of FHF for treating vaginitis remain unreported, and further preclinical evaluation is required to reveal its potential pharmacological activities against vaginitis.
Huiyu Liu   +5 more
wiley   +1 more source

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