Results 81 to 90 of about 553,116 (313)

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Genomic modeling of hepatitis B virus integration frequency in the human genome.

PLoS ONE, 2019
Hepatitis B infection is a world-wide public health burden causing serious liver complications. Previous studies suggest that hepatitis B integration into the human genome plays a crucial role in triggering oncogenic process and may also constitutively ...
Ondrej Podlaha, George Wu, Bryan Downie, Raghuraman Ramamurthy, Anuj Gaggar, Mani Subramanian, Zhishen Ye, Zhaoshi Jiang   +7 more
doaj   +1 more source

Seroprevalence of viral hepatitis in riverine communities from the Western Region of the Brazilian Amazon Basin

Memorias do Instituto Oswaldo Cruz, 2001
The western region of the Brazilian Amazon Basin has long been shown to be a highly endemic area for hepatitis B and hepatitis D viruses. Data concerning the prevalence of hepatitis C and E viruses in this region are still scarce.
VS de Paula, ME Arruda, CL Vitral, AMC Gaspar   +3 more
doaj   +1 more source

Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen

Journal of Experimental Medicine, 1991
The absence of readily manipulable experimental systems to study the cytotoxic T lymphocyte (CTL) response against hepatitis B virus (HBV) antigens has thus far precluded a definitive demonstration of the role played by this response in the pathogenesis ...
A. Penna, F. Chisari, A. Bertoletti, G. Missale, T. Giuberti, S. Marchelli, L. Galati, F. Fiaccadori, C. Ferrari   +8 more
semanticscholar   +1 more source

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 CAR‐T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, Accepted Article.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T‐cell therapy in patients with progressive systemic sclerosis. Methods Patients with progressive systemic sclerosis received CD19 CAR‐T cell therapy and were followed longitudinally for safety, clinical efficacy, immune ...
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Dane Complexes in Hepatitis B Antigen

Journal of General Virology, 1974
Summary Complexes consisting of only Dane particles are found frequently in Hepatitis B antigen-positive sera. It is proposed that the reason for their presence is the existence of a third antigen-antibody system involving the Dane coat material but not the small spheres or tubules.
J, Moodie, L M, Stannard, A, Kipps
openaire   +2 more sources

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Hepatitis B surface antigen prevalence in pregnant women before and after national vaccinations

Инфекция и иммунитет
Background. Hepatitis B in pregnant mothers can pose a risk to both the mother and the baby. If left untreated or undiagnosed, hepatitis B can be passed from mother to child during childbirth, leading to chronic hepatitis B infection in the baby. However,
Faeghe Hedayati, Sam Lotfi, Pouyan Ebrahimi, Mostafa Javanian, Fatemeh Bayani, Zeinab Darbandi, Masomeh Bayani   +6 more
doaj   +1 more source

Glycoproteins Associated with Hepatitis B Antigen

Intervirology, 1973
The total carbohydrate content of purified hepatitis B antigen (HB Ag) ranged between 3.6 and 6.5% as determined by the phenol-sulfuric acid method. Disc-sodium dodecyl sulfate PAGE of purified HB Ag followed by periodate-Schiff staining revealed one major and two minor glycoproteins with molecular weights of 22,000,27,000 and 32,000 daltons ...
R, Chairez, S, Steiner, J L, Melnick, G R, Dreesman   +3 more
openaire   +2 more sources