Results 101 to 110 of about 138,424 (357)
Human Cyclophilins—An Emerging Class of Drug Targets
Medicinal Research Reviews, EarlyView.ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova +3 more
wiley +1 more source
Late results of the Royal Free Hospital prospective controlled trial of prednisolone therapy in hepatitis B surface antigen negative chronic active hepatitis. [PDF]
, 1980 Andrew Kirk +4 more
openalex +1 more source
The Cinderella tree, Quillaja saponaria – A soap story
PLANTS, PEOPLE, PLANET, EarlyView.Our current understanding of plants has been shaped by the entwining of different cultures. The Chilean soapbark tree, traditionally valued as a source of natural soap, was shown by serendipitous research in France in the 1900s to produce compounds that can boost the immune response to vaccines.
Anne Osbourn
wiley +1 more source
PLANTS, PEOPLE, PLANET, EarlyView.Plants, like humans, have a microbiome that helps them grow, defend themselves against pathogens, acquire nutrients, and protect themselves against environmental stresses. The microbiome of tomatoes, a staple crop grown worldwide, could be utilized not only to reduce fertilizer and pesticide applications, but also to clean up harmful pollutants ...
Sean Lindert +3 more
wiley +1 more source
The Potential Role of Metabolic Disease in Liver Tumorigenesis in Patients With Hepatitis B Surface Antigen Seroclearance [PDF]
, 2019 Hao Zhang, Wenting Zeng
openalex +1 more source
Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux +6 more
wiley +1 more source
Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing
Small, EarlyView.The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa +4 more
wiley +1 more source
Beads‐on‐a‐Tip testing for ultrasensitive antigen detection across a large dynamic range
Smart Molecules, EarlyView.Non‐specific adsorption on nitrocellulose membranes limits the sensitivity of conventional lateral flow immunoassays. Here, we present a Beads‐on‐a‐Tip immunoassay that replaces the membrane with magnetic beads for antigen capture and enrichment, while employing upconversion nanoparticles as background‐free luminescent reporters.
Ziwei Wu +6 more
wiley +1 more source