Results 161 to 170 of about 283,560 (208)
Mycophenolate mofetil (MMF) is an immunosuppressive drug widely used by solid organ transplant recipients. Although it is known that MMF suppresses immune responses, its exact effects on specific vaccinations have not been investigated yet. Mucosal vaccinations are increasingly used, such as a cholera vaccination consisting of two oral immunizations ...
Boukje C. Eveleens Maarse +4 more
wiley +1 more source
ABSTRACT Issue Addressed This study assesses how the concept of (health) research impact has been operationalised in National Health and Medical Research Council (NHMRC) Impact Case Studies, and if and how lived experience research priorities have been considered, to ascertain implications for Australian health and medical research.
Nizam Abdu +6 more
wiley +1 more source
ABSTRACT Background and Aims Hepatitis B virus (HBV) infection remains a global health concern, with nurses being particularly vulnerable to occupational exposure. In Bangladesh, however, there is limited understanding of the knowledge, attitudes, and practices (KAP) of nurses concerning HBV, highlighting a significant gap in research and awareness ...
Salekur Rahman +11 more
wiley +1 more source
A novel nanoformulation consisting of ampicillin (Amp), l‐glutamic acid (l‐glu), and iron oxide nanoparticles was prepared. l‐glu–Fe3O4–Amp NPs exhibited a controlled drug release profile over a certain period of time. The antibacterial effectiveness of the formulation was proven by agar well diffusion and the LIVE/DEAD BacLight fluorescent assays. The
Mehmet Demirel +6 more
wiley +1 more source
This review delineates the multifaceted roles of natural killer (NK) cells in the central nervous system, spanning direct cytolysis, immunoregulation, and crosstalk with the brain microenvironment. We evaluate the translational potential and challenges of NK cell immunotherapies for a spectrum of neurological conditions.
Kaihang Deng, Wai Po Chong
wiley +1 more source
Mucosal‐Associated Invariant T Cells in Health and Disease
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao +5 more
wiley +1 more source
ABSTRACT Tocilizumab is an interleukin‐6 (IL‐6) receptor antagonist indicated for various rheumatologic conditions. While hepatotoxicity is a recognized adverse effect, it predominantly manifests as hepatocellular injury. We report a rare case of drug‐induced liver injury (DILI) presenting with a cholestatic pattern and cholangitis features in a 75 ...
Louis‐Edmond Barbaro +7 more
wiley +1 more source
Evasins: Biology and Therapeutic Potential of Broad‐Spectrum Chemokine Inhibitors
ABSTRACT Ticks are haematophagous parasites that rely on uninterrupted bloodmeals for survival and need an effective strategy to suppress the host inflammatory response. Leukocyte recruitment is a chemokine‐mediated hallmark of inflammation, which ticks counteract via anti‐chemokine proteins in their saliva named evasins.
Emilia L. Bialek +3 more
wiley +1 more source
Abstract Background and Purpose Rare but severe adverse events (AEs) associated with mRNA‐lipid nanoparticle (LNP) COVID‐19 vaccines, such as Comirnaty, include anaphylaxis and inflammatory organ disorders, but their underlying mechanisms are poorly understood. We aimed to develop an animal model to study these phenomena.
László Dézsi +13 more
wiley +1 more source

