Results 11 to 20 of about 397,978 (363)

A Multivalent mRNA Therapeutic Vaccine Exhibits Breakthroughs in Immune Tolerance and Virological Suppression of HBV by Stably Presenting the Pre-S Antigen on the Cell Membrane [PDF]

Pharmaceutics
Background/Objectives: In chronic hepatitis B infection (CHB), the hepatitis B surface antigen (HBsAg) continuously exhausts the hepatitis B surface antibody (HBsAb), which leads to the formation of immune tolerance.
Shang Liu, Jie Wang, Yunxuan Li, Muhan Wang, Pei Du, Zhijie Zhang, Wenguo Li, Rongchen Sun, Mingtao Fan, Meijia Yang, Hongping Yin   +10 more
doaj   +2 more sources

Effects of combined immunosuppressant and hepatitis B virus antiviral use on COVID-19 vaccination in recipients of living donor liver transplantation [PDF]

PeerJ
Background & Aims The global pandemic caused by the highly contagious SARS-CoV-2 virus led to the emergency approval of COVID-19 vaccines to reduce rising morbidity and mortality.
Ryunjin Lee, Jiwan Choi, Eunkyeong Lee, Jooyoung Lee, Jiye Kim, Seoon Kang, Hye-In An, Sung-Han Kim, Sung-Min Kim, Eun-Kyoung Jwa, Gil-Chun Park, Jung-Man Namgoong, Gi-Won Song, Young-In Yoon, Eunyoung Tak, Sung-Gyu Lee   +15 more
doaj   +3 more sources

Mission 2030: Toward universal hepatitis B immunization [PDF]

Human Vaccines & Immunotherapeutics
Despite the availability of efficacious and safe vaccines for more than 40 years, the rate of new hepatitis B virus (HBV) infections remains high, leaving large populations at risk of developing chronic hepatitis B, liver cirrhosis and cancer.
Elias Broeckhoven, Kai Dallmeier
doaj   +2 more sources

Scientific approaches to defining HPV vaccine-induced protective immunity. [PDF]

Int J Cancer
Abstract Seventeen years after the licensure of prophylactic human papillomavirus (HPV) L1 virus‐like‐particle vaccines, a defined antibody level that correlates with vaccine‐induced protection against HPV infections and associated neoplasia is missing.
Lehtinen M, van Damme P, Beddows S, Pinto LA, Mariz F, Gray P, Dillner J.   +6 more
europepmc   +2 more sources

Cost‐effectiveness of second‐line therapies in adults with chronic immune thrombocytopenia

American Journal of Hematology, Volume 98, Issue 1, Page 122-130, January 2023., 2023
Abstract Major options for second‐line therapy in adults with chronic immune thrombocytopenia (ITP) include splenectomy, rituximab, and thrombopoietin receptor agonists (TRAs). The American Society of Hematology guidelines recommend rituximab over splenectomy, TRAs over rituximab, and splenectomy or TRAs while noting a lack of evidence on the cost ...
George Goshua, Pranay Sinha, Natalia Kunst, Lauren Pischel, Alfred Ian Lee, Adam Cuker   +5 more
wiley   +1 more source

Current updates of CRISPR/Cas9‐mediated genome editing and targeting within tumor cells: an innovative strategy of cancer management

Cancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022
Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem, Mohammed A Alsahli, Ahmad Almatroudi, Faris Alrumaihi, Fahd Khaleefah Alkhaleefah, Arshad Husain Rahmani, Amjad Ali Khan   +6 more
wiley   +1 more source

Advances in exosome biomarkers for cervical cancer

Cancer Medicine, Volume 11, Issue 24, Page 4966-4978, December 2022., 2022
Cancer‐derived exosomes may promote CC metastasis by boosting cellular epithelial‐mesenchymal transformation (EMT), controlling the proliferation, invasion, or migration of cancer cells, as well as influencing immune escape and aiding angiogenesis.
Zihan Ran, Shaobo Wu, Zijng Ma, Xiuwen Chen, Jing Liu, Jingcheng Yang   +5 more
wiley   +1 more source

Clinical and laboratory profile and outcomes of hospitalized COVID‐19 patients with type 2 diabetes mellitus in Ghana – A single‐center study

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
This study describes the clinical and laboratory profile and outcomes of hospitalized COVID‐19 patients with type 2 diabetes mellitus (DM) in Ghana. Out of 175 patients (mean age 55.9+/−18.3 years) 64 (36.6%) had DM. Compared to non‐diabetics, DM patients were older (61.1? 12.8 vs. 53.0?
Yasmine Oladele Hardy, Elena Libhaber, Emmanuel Ofori, Divine Aseye Yao Amenuke, Samuel Amoabeng Kontoh, James Amoah Dankwah, Rita Larsen‐Reindorf, Caleb Otu‐Ansah, Kojo Hutton‐Mensah, Ebenezer Dadson, Sheila Adamu, Kofi Akyerekoh, Fred Stephen Sarfo, Bernard Nkum   +13 more
wiley   +1 more source

Oligonucleotide separation techniques for purification and analysis: What can we learn for today's tasks?

ELECTROPHORESIS, Volume 43, Issue 23-24, Page 2402-2427, December 2022., 2022
Abstract Nucleic acids are the blueprint of life. They are not only the construction plan of the single cell or higher associations of them, but also necessary for function, communication and regulation. Due to the pandemic, the attention shifted in particular to their therapeutic potential as a vaccine. As pharmaceutical oligonucleotides are unique in
Robert Minkner, Jirayu Boonyakida, Enoch Y. Park, Hermann Wätzig   +3 more
wiley   +1 more source

Maternal Infection with Trypanosoma cruzi and Congenital Chagas Disease Induce a Trend to a Type 1 Polarization of Infant Immune Responses to Vaccines [PDF]

, 2009
Vaccines are of crucial importance to prevent morbidity and mortality due to infectious diseases in childhood. A modulation of the fetal/neonatal immune system (considered immature) toward Th1 or Th2 dominance could modify responses to vaccines ...
A Acosta-Serrano, A Marchant, A Marchant, A Ouaissi, AD Labeaud, Amilcar Flores, C Riera, CA Siegrist, CA Siegrist, Carine Truyens, CJ Schofield, CM Snapper, Cristina Alonso-Vega, D Elias, DJ West, DT Avery, E Hermann, E Hermann, Eduardo Suarez, Edward T. Ryan, Emmanuel Hermann, F Mascart, F Mascart, F Torrico, Faustino Torrico, GA Schmunis, H Gregorek, HM Hasselhorn, I Malhotra, IC Almeida, J Jannin, J Munoz, J Vekemans, J Vekemans, K Brustoski, K Kaur, K Sadeghi, M Virreira, Marisol Córdova, ME Rossi, MJ Saffar, MO Ota, Nicolas Dauby, O Garraud, O Simonsen, P Buekens, R Sathler-Avelar, RA Murray, RA Seder, SD Blackburn, SF Neves, Tatiana Tellez, TM Doherty, V Kasprowicz, VM Caceres, Y Carlier, Y Carlier, Y Carlier, Y Jackson, Yves Carlier   +59 more
core   +3 more sources