Results 271 to 280 of about 130,240 (311)

CRISPR‐driven diagnostics: Molecular mechanisms, clinical efficacy and translational challenges

Clinical and Translational Medicine, Volume 15, Issue 10, October 2025.
The CRISPR/Cas system has emerged as a transformative tool in the field of molecular diagnosis, offering unprecedented sensitivity, specificity and rapid detection capabilities. This review further examines the molecular mechanisms of CRISPR tools, compares their clinical efficacy with traditional methods and highlights cutting‐edge innovations such as
Zilong Wang, Qianqian Wang, Jiaming Zhang, Bingyu Li, Yuke Li, Zhengbo Chen, Dandan Guo, Shuying Feng   +7 more
wiley   +1 more source

Iron deficiency and vaccine efficacy: A mini-review of immunological interplay and evidence across vaccine types. [PDF]

Hum Vaccin Immunother
Mohammed J, Parveen A, Ubaid Chhapra H, Naaz Mashooq F, Shadan M.   +4 more
europepmc   +1 more source

Socioeconomic determinants of vaccination against pneumococcus in 763 945 patients with heart failure

ESC Heart Failure, Volume 12, Issue 5, Page 3750-3754, October 2025.
Respiratory infections heighten risks for heart failure (HF) patients, yet 2020 data from France show low vaccination rates: 12.6% for pneumococcus and 63.1% for influenza. Using logistic regression on 763,945 HF patients, older age, female sex, and social deprivation were associated with lower pneumococcus vaccination, despite frequent healthcare ...
F. Roubille, B. Wyplosz, J. Fernandes, B. Grenier, F. Raguideau, E. Blanc, G. Goussiaume   +6 more
wiley   +1 more source

Administration of the NOD2 Agonist MDP Reduces Cryptosporidium parvum Infection in Neonatal Mice Through IL‐22 Involvement

European Journal of Immunology, Volume 55, Issue 10, October 2025.
Neonatal mice infected with C. parvum and treated with MDP, a NOD2 agonist, exhibited reduced intestinal infection. This protective effect was mediated by a local immune response involving neutrophil recruitment, IL‐22 production, antimicrobial peptide expression, and epithelial regeneration in an IFN‐γ‐dependent manner.
Mégane Fernandez, Tiffany Pezier, Julien Pichon, Yves Le Vern, Catherine Werts, Sonia Lacroix‐Lamandé   +5 more
wiley   +1 more source

Risk of tuberculosis and hepatitis B reactivation during adalimumab use in the treatment of hidradenitis suppurativa. [PDF]

Sci Rep
Karakoyun Ö, Ayhan E.
europepmc   +1 more source

EHA–EU MCL network guidelines for diagnosis and treatment of mantle cell lymphoma

HemaSphere, Volume 9, Issue 10, October 2025.
Abstract Mantle cell lymphoma (MCL) is a relatively rare B‐cell lymphoma subtype, with a higher incidence among males and a median age of 70 years at diagnosis. MCL is characterized by clinically diverse behavior, from indolent disease to extremely aggressive, related to the presence of biological risk factors such as proliferation rate and TP53 ...
Mats Jerkeman, Igor Aurer, Elias Campo, Chan Y. Cheah, Jonathan Clark, Jeanette Doorduijn, Toby A. Eyre, Martin Fehr, Eva Giné, Maria Gomes da Silva, Pavel Klener, Marco Ladetto, Vincent Ribrag, Ofer Shpilberg, Jan Walewski, Martin Dreyling, the EHA Guidelines Committee and the European MCL Network   +16 more
wiley   +1 more source

Human papillomavirus, sexually transmitted infections, and antimicrobial resistance in West Africa: Estimating population burden and understanding exposures to accelerate vaccine impact and drive new interventions: The PHASE survey protocol. [PDF]

PLoS One
Bashorun AO, Kotei L, Jallow AF, Jawla O, Richard-Ugwuadu EU, Jagana M, Bah L, Bah AT, Conteh K, Jallow MSK, Karim M, Dondeh BL, Segonds-Pichon A, Clifford GM, Baussano I, Pichon B, Jeffries D, Clarke E.   +17 more
europepmc   +1 more source

Mapping the cancer vaccine landscape. [PDF]

J Immunother Cancer
Hu F, Li H, Lv W, Li M, Gale RP, Huang X, Liang Y.   +6 more
europepmc   +1 more source

Prevalence and Associated Factors of Needlestick and Sharp Injuries Among Healthcare Workers in a Tertiary Care Hospital, Mogadishu, Somalia: A Prospective Single‐Center Study

Health Science Reports, Volume 8, Issue 10, October 2025.
ABSTRACT Background Needlestick and sharp injuries (NSSIs) represent a major occupational hazard for healthcare workers (HCWs), posing serious health risks and psychological stress. Globally, millions of HCWs experience such injuries each year, with the burden disproportionately higher in low‐resource settings.
Suad Abdikarim Isse, Mohamed Abdirahim Omar, Ahmet Doğan, Ali Kutta Çelik, Tigad Abdisad Ali, Sultan Pir, Sowda Abdikarim Sheikh, Jabir Abdullahi Wehlie, Rahma Yusuf Haji Mohamud, Ahmed Mohamed Ali, Liban Ade Hussein, Iftin Mohamed Osman, Ifrah Adan Hilowle   +12 more
wiley   +1 more source

Nanocarrier-based immunotherapy for viral diseases. [PDF]

Int J Pharm X
Liu D, Zhao T, Li Y, Huang L, Che J, Zou P, Yang W, Ding J, Wu P, Gao X, Ran Y, Sun H, Li Z, Gao J, Gao C.   +14 more
europepmc   +1 more source