Results 71 to 80 of about 645,099 (360)

Occult hepatitis B virus infection and its demographic and clinical determinants among blood donors in Saudi Arabia: A retrospective cross-sectional study

Journal of International Medical Research
Objective Occult hepatitis B virus infection, characterized by the presence of hepatitis B virus DNA in the absence of detectable hepatitis B surface antigen, poses a significant risk to blood donation safety. This study aimed to determine the prevalence
Abdulrahman F Alrezaihi, Lama Alzamil, Abdulrahman Alshalani, Jawaher Alsughayyir, Fahad S Alshehri, Abdulaziz M Almuqrin   +5 more
doaj   +1 more source

EZH2-mediated epigenetic silencing of tumor-suppressive let-7c/miR-99a cluster by hepatitis B virus X antigen enhances hepatocellular carcinoma progression and metastasis [PDF]

, 2023
Chen-Shiou Wu, Yi‐Chung Chien, Chia‐Jui Yen, Jiayan Wu, Li‐Yuan Bai, Yung‐Luen Yu   +5 more
openalex   +1 more source

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection

Signal Transduction and Targeted Therapy
This study aimed to develop a pan-genotypic and multifunctional small interfering RNA (siRNA) against hepatitis B virus (HBV) with an efficient delivery system for treating chronic hepatitis B (CHB), and explore combined RNA interference (RNAi) and ...
Wenjing Zai, Min Yang, Kuan Jiang, Juan Guan, Huijing Wang, Kongying Hu, Chao Huang, Jieliang Chen, Wei Fu, Changyou Zhan, Zhenghong Yuan   +10 more
doaj   +1 more source

The Serumal Concentration of Hbsag in Patiets with Chb/hiv Co-infection Comparing with Chb Mono-infection in the Different Phases of Natural Course of Chronic Hepatitis В [PDF]

, 2016
The prevalence and inclination to chronization of viral hepatitis B is 3 – 5 times higher in patients with HIV-infection than in HIV-negative ones. The natural clinical course of chronic hepatitis B (CHB) in patients with HIV has the features, connected ...
Melnyk, T. (Tetiana), Moroz, L. (Larisa)
core  

Prevention of Hepatitis B Virus Transmission in Pregnancy [PDF]

, 2014
Chronic hepatitis B virus infection is a serious health problem in many countries, particularly in developing countries. In Asia-Pacific region, vertical transmission from mother to child is the main endemicity factor of hepatitis B virus (HBV) infection.
Praptiwi, D. R. (Dwi), Sanityoso, A. (Andri)   +1 more
core   +1 more source

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, EarlyView.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

Seroprevalence of hepatitis B and C viruses among waste handlers in Ethiopia: A systematic review and meta-analysis

SAGE Open Medicine
Objective: Hepatitis B virus and hepatitis C virus are the leading causes of global liver-related morbidity and mortality. Waste handlers are one of the high-risk groups for hepatitis B virus and hepatitis C virus acquisition. Thus, the aim of this study
Alemu Gedefie, Fekadeselassie Belege Getaneh, Habtu Debash, Saleamlak Sebsibe, Yonas Erkihun, Ermiyas Alemayehu, Yeshi Metaferia, Yeshimebet Kassa, Agumas Shibabaw, Mihret Tilahun, Getachew Mesfin Bambo, Samuel Sahile Kebede, Mekuanent Alemu, Wondmagegn Demsiss   +13 more
doaj   +1 more source

Diagnostic Dilemma for Low Viremia with Significant Fibrosis; is Hepatitis B Virus DNA Threshold Level a Good Indicator for Predicting Liver Damage?

Balkan Medical Journal, 2018
Background: The most important difficulties about management of hepatitis B are still determining the liver damage and the right time to start antiviral therapy.
Ercan Yenilmez, Rıza Aytaç Çetinkaya, Ersin Tural   +2 more
doaj   +1 more source

The natural history of chronic hepatitis B infection [PDF]

, 1997
Chronic hepatitis B infection is a global health problem that affects about 300 million people. Of these, 75% are Chinese. Most Chinese who become chronic carriers, contract the virus during the perinatal period.
Lai, CL, Lau, GKK, Wu, PC
core