Results 151 to 160 of about 186,361 (263)

Immune Checkpoint Inhibitors Induce Intestinal Epithelial Injury and a Senescence‐Like Phenotype

iNew Medicine, EarlyView.
ICI treatment promotes the infiltration of activated immune cells into the intestinal mucosa. This inflammatory microenvironment is associated with significant epithelial injury, characterized by the disruption of the epithelial barrier, the depletion of specialized secretory cell lineages, and the induction of a premature senescence phenotype ...
Juan Wang, Shuang Wu, Shuangbiao Wei, Weizhen Xiang, Jianshang Huang, Lei Xiong, Hua Wang, Li Zuo   +7 more
wiley   +1 more source

Molecular, serological, and epidemiological characterisation of a hepatitis A virus outbreak in Maharashtra, India, 2025. [PDF]

Indian J Med Res
Tomar S, Hansraj Pise K, Ramdasi A, Hundekar S, Deoshatwar AR, Thorat N, Jawalkar P, Ayachit P, Mahesh Kulkarni P, Nagargoje BB, Vishwanath Tandale B, Shete Aich A.   +11 more
europepmc   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Prevalence of Hepatitis E Virus Infection Among Pregnant Women in Tunisia: Findings from a Large Cohort Study. [PDF]

Pathogens
Ayouni K, Gdoura M, Allègue R, Ameur MB, Touzi H, Abderahmane N, Magdoud K, Mkadmi H, Hmid RB, Triki H, Chouikha A.   +10 more
europepmc   +1 more source

Zinc Finger E‐Box Binding Homeobox 1 Mediates Alcohol‐Induced Liver Disease

iNew Medicine, EarlyView.
Alcohol intake leads to the upregulation of ZEB1, which activates the YAP‐IL‐1β/MCP‐1 pathway, resulting in the activation of liver inflammation and the induction of hepatocyte apoptosis. ABSTRACT Objective Hepatitis resulting from alcoholic liver disease (ALD) is an important risk factor for liver cancer.
Boyu Zhang, Chunyang Zhang, Xiao Cui, Tao Xu, Xiangpeng Hu, Jiong Gu   +5 more
wiley   +1 more source

Epstein-Barr Virus in Brain Cancer-Friend or Foe? [PDF]

Int J Mol Sci
Brzozowski M, Góralczyk M, Bogacki S, Polz-Dacewicz M.   +3 more
europepmc   +1 more source

Western Diet Combined With Chemical Induction: A Strategy for Rapid Development of MASLD Pathology in Mice

iNew Medicine, EarlyView.
ABSTRACT Objective The molecular mechanisms underlying the development of metabolic‐dysfunction‐associated steatotic liver disease (MASLD) are essential for developing appropriate treatments. The purpose of this study was to establish an MASLD model in mice with rapid and consistent progression.
Ting‐Ting Chen, Nan Li, Shuo Wang, Miao Sun, Rui Yang, Shi‐Hao Zhang, Xiao‐Lei Li, Chen Dong, Ke‐Yuan Chen, Wu‐Yi Sun, Na Zhou   +10 more
wiley   +1 more source

Autoantibodies in the follow-up of autoimmune hepatitis. [PDF]

J Transl Autoimmun
Nagy G, Bencze D, Demeter S, Pénzes-Daku K, Szabó L, Tóth B, Földesi R, Papp M, Antal-Szalmás P.   +8 more
europepmc   +1 more source

Integrated one‐pot CRISPR‐Cas detection: Addressing strategies and future prospects

Interdisciplinary Medicine, EarlyView.
Integrated one‐pot CRISPR‐Cas detection significantly simplifies workflows, reduces cross‐contamination risks, and shortens turnaround times, making it highly suitable for point‐of‐care testing (POCT) and resource‐limited settings. Key challenges include system compatibility issues between Cas proteins and isothermal amplification, limited multiplexing
Jian Zhou, Xuemei Ren, Yingjie Ren, Ruiping Wu, Ruiman Geng, Le Chen, Zhuo Li   +6 more
wiley   +1 more source

Case Report: Two atypical cases of M6-like antimitochondrial antibody pattern unlinked to iproniazid. [PDF]

Front Immunol
Tolmer E, Bonnet B, Jeannin G, Junda M, Godignon M, Evrard B.   +5 more
europepmc   +1 more source