Results 111 to 120 of about 911,773 (309)

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

Improvement of patient-reported outcomes in patients achieving sustained virologic response with direct-acting antivirals for hepatitis C virus infection

, 2022
Chih‐Hsun Yi, Ming‐Jong Bair, Jen‐Hung Wang, Ming‐Wun Wong, Tso‐Tsai Liu, Wei‐Yi Lei, Shu‐Wei Liang, Lin Lin, Jui‐Sheng Hung, Jee‐Fu Huang, Yao‐Chun Hsu, Chien‐Lin Chen   +11 more
openalex   +1 more source

The prevalence of hepatitis C virus infection in the United States, 1988 through 1994.

New England Journal of Medicine, 1999
M. J. Alter, D. Kruszon-Moran, O. Nainan, G. Mcquillan, Fengxiang Gao, L. Moyer, Richard A. Kaslow, H. Margolis   +7 more
semanticscholar   +1 more source

Comparison of Anatomical and Non‐Anatomical Resection in Low Microvascular Invasion Risk Solitary Hepatocellular Carcinoma ≤ 5 cm

Annals of Gastroenterological Surgery, EarlyView.
We evaluated whether anatomical resection (AR) provides an oncological benefit over non‐anatomical resection (NAR) in solitary hepatocellular carcinoma ≤ 5 cm without predicted microvascular invasion or intrahepatic metastasis, identified by preoperative DCP ≤ 150 mAU/mL.
Norifumi Iseda, Shinji Itoh, Kyohei Yugawa, Shohei Yoshiya, Takashi Motomura, Takeo Toshima, Tomoharu Yoshizumi   +6 more
wiley   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Establishment Of A Hepatitis C Virus (Hcv) Cohort In A Large Israeli Hmo [PDF]

, 2014
Varda Shalev, Carol J. Weil, C. Nwankwo, M. Friedman, Gili Kenet, G. Chodick   +5 more
openalex   +1 more source

Telaprevir for previously untreated chronic hepatitis C virus infection.

New England Journal of Medicine, 2011
I. Jacobson, J. Mchutchison, G. Dusheiko, A. Bisceglie, K. Reddy, N. Bzowej, P. Marcellin, A. Muir, P. Ferenci, R. Flisiak, J. George, M. Rizzetto, D. Shouval, R. Solá, R. Terg, E. Yoshida, N. Adda, L. Bengtsson, A. Sankoh, Tara L. Kieffer, S. George, R. Kauffman, S. Zeuzem, V. Phar   +23 more
semanticscholar   +1 more source

Association of HAMP Expression and CD8+ T‐Cell Infiltration With Atezolizumab–Bevacizumab Response in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
In hepatocellular carcinoma treated with atezolizumab–bevacizumab, responders showed RNA‐seq enrichment of immune and chemokine pathways with higher HAMP expression. In resected specimens, immunohistochemistry confirmed increased intratumoral CD8+ T‐cell density and hepcidin (HAMP), supporting HAMP plus CD8 as components of a composite predictor of ...
Shun Nakamura, Yuki Murakami, Yusuke Oshima, Takashi Masuda, Wataru Miyoshino, Hiroomi Takayama, Yoko Kawano, Teijiro Hirashita, Yuichi Endo, Masafumi Inomata   +9 more
wiley   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Global epidemiology and genotype distribution of the hepatitis C virus infection.

Journal of Hepatology, 2014
E. Gower, C. Estes, S. Blach, K. Razavi‐Shearer, H. Razavi   +4 more
semanticscholar   +1 more source