Results 151 to 160 of about 1,173,658 (399)

Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels

Advanced Science, EarlyView.
A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Xiaohan Liu, Zhihao Xu, Yilun Tong, Changtai Wang, Yueqi Yao, Yujie Diao, Jingyuan Ma, Shijun Zhou, Yinan Du, Zhenhua Zhang, Gang Xu   +10 more
wiley   +1 more source

Eliminating Structural Barriers: The Impact of Unrestricted Access on Hepatitis C Treatment Uptake Among People Living With Human Immunodeficiency Virus [PDF]

, 2019
Sahar Saeed, Erin Strumpf, Erica E. M. Moodie, Leo Wong, Joseph Cox, Sharon Walmsley, Mark Tyndall, Curtis Cooper, Brian Conway, Mark Hull, Valérie Martel‐Laferrière, M. John Gill, Alexander Wong, Marie-Louise Vachon, Marina B. Klein, Lisa Barrett, Jeff Cohen, Brian Conway, Curtis Cooper, Pierre Côté, Joseph Cox, M. John Gill, Shariq Haider, Mark Hull, Marina B. Klein, Joan Montaner, Erica E. M. Moodie, Neora Pick, Anita Rachlis, Danielle Rouleau, Aida Sadr, Stephen Sanche, Roger Sandre, Mark Tyndall, Marie-Louise Vachon, Sharon Walmsley, Alex Wong, M B K Saskatchewan   +37 more
openalex   +1 more source

Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis

, 2021
José Carlos Rodrigues Nascimento, Lianna Cavalcante Pereira, Juliana Magalhães da Cunha Rêgo, Ronaldo Pereira Dias, Paulo Goberlânio B Silva, Silvio Alencar C Sobrinho, Gustavo Coelho, Ivelise Regina Canito Brasil, Edmilson Ferreira de Oliveira-Filho, James S. Owen, Pierluigi Toniutto, Reinaldo B. Oriá   +11 more
openalex   +1 more source

Hepatitis C virus NS3-4A protease regulates the lipid environment for RNA replication by cleaving host enzyme 24-dehydrocholesterol reductase [PDF]

, 2020
Lorillee Tallorin, Valerie A. Villareal, Chih‐Yun Hsia, Mary A. Rodgers, Dominique J. Burri, Marc-Philipp Pfeil, Paula Montero Llopis, Brett D. Lindenbach, Priscilla L. Yang   +8 more
openalex   +1 more source

RNAi Regulator C3PO Promotes Arbovirus Infection in Insect Vectors

Advanced Science, EarlyView.
RNA interference (RNAi) is vital for eukaryotes to defend against virus infection. The C3PO complex takes part in RNAi but its role in regulating viral infection remains unclear. This work finds that insect C3PO facilitates arbovirus replication by degrading precursors of miRNAs, especially miR‐971‐3p.
Yan Xiao, Tianyu Guan, Qianfeng Xia, Chen Chen, Qian Wang, Lan Luo, Hong Lu, Feng Cui   +7 more
wiley   +1 more source

Hepatitis B/C virus co-infection in Iran: A seroepidemiological study [PDF]

, 2007
Background/aims: As hepatitis B and C virus have the same transmission routes, dual infection may occur. The aim of this study was to determine the seroprevalence of HCV in HBsAg-positive subjects.
Abdolahi, N., Besharat, S., Danesh, A., Hosseini, S.A., Jabbari, A., Joshaghani, H., Kabir, M.J., Kalavi, K., Keshtkar, A.A., Moradi, A., Roshandel, D., Roshandel, G., Sedaqat, S.M., Semnani, S.   +13 more
core  

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

Chronic Viral Hepatitis: Etiology, Pathogenesis of Liver Damage and Mechanisms of Persistence [PDF]

, 2004
Chronic hepatotropic viruses commonly evade the antiviral defence systems of the body and cause a long - lasting persistent infection. The prolonged nature of the infection ensures that every infected person has ample opportunity to transmit the virus to
Setiabudi, I. (Irwan)
core  

Benefit‐risk assessment for sofosbuvir/velpatasvir/voxilaprevir based on patient population and hepatitis C virus genotype: U. S. Food and Drug Administration's evaluation [PDF]

, 2017
Kimberly Struble, Kirk M. Chan‐Tack, Karen Qi, Lisa K. Naeger, Debra Birnkrant   +4 more
openalex   +1 more source

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source