Results 111 to 120 of about 551,277 (339)
Advanced Science, EarlyView.Macrophage phenotypes are influenced by the microenvironment. Matrix stiffness, a key ECM factor, polarizes macrophage toward a pro‐regenerative phenotype in a 3D physiological environment. CaMKK2 selectively regulates stiffness‐induced macrophage polarization, impacting tumor growth and wound healing.
Ya Guan +7 more
wiley +1 more source
Hepatitis B antigen-associated deoxyribonucleic acid polymerase activity and e antigen/anti-e system [PDF]
, 1976 Masayuki Imai +4 more
openalex +1 more source
DeckerMed Gastroenterology, Hepatology and Endoscopy, 2018 Hepatitis E Virus (HEV) infections are among the most frequent causes of viral hepatitis globally. They are especially common in southern Asia where large epidemics of waterborne hepatitis, primarily affect adults with increased mortality in pregnant women, occur frequently during and after monsoon rains when there is contamination of the drinking ...
Brittany L. Kmush, Kenrad E. Nelson
openaire +1 more source
Advanced Science, EarlyView.Liver fibrosis is a growing global health burden with no specific treatment. HSC activation is the predominant driver of liver fibrogenesis and the current focus in antifibrotic drug discovery. This study identifies autocrine GDF10 activates BMPR2/ALK3‐SMAD1/5/8‐SMAD7 pathway to counteract the TGF‐β‐SMAD2/3 pathway in HSCs, thereby inhibiting HSC ...
Yinliang Zhang +16 more
wiley +1 more source
Advanced Science, EarlyView.Targeted regulation of pyroptosis to modulate the immune landscape is a novel design strategy for cancer immunotherapy and anti‐inflammatory treatment. Pyroptosis, as a double‐edged sword, underscores the importance of optimizing the design strategy of functional materials and appropriately activating pyroptosis for the effective treatment of diseases.
Luyao Tian +5 more
wiley +1 more source
Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease
Advanced Science, EarlyView.The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su +12 more
wiley +1 more source
MicroRNA‐433‐3p enhances chemosensitivity of glioma to cisplatin by downregulating NR5A2
Brain and Behavior, Volume 12, Issue 12, December 2022., 2022 miR‐433‐3p mediated the ability of NR5A2 to regulate the malignant behavior of glioma cells Abstract Objective We attempted to investigate influence of microRNA‐433‐3p on malignant progression of glioma and identify its molecular mechanism, thus laying groundwork for glioma management.
Jun Li +9 more
wiley +1 more source
A CASE OF IMPORT OF GENOTYPE 4 HEPATITIS E VIRUS INTO RUSSIA
Журнал микробиологии, эпидемиологии и иммунобиологии, 2016 Aim. Description of the first documented case of imported hepatitis E, associated with genotype 4 of HEV and introduced from southern France. Materials and methods.
M. I. Mikhailov +3 more
doaj +1 more source
Advanced Science, EarlyView.PDCD11 overexpression highly correlates to poor prognosis in p53‐mutant breast and colon cancers. Through interaction with C‐MYC in the nucleoplasm, PDCD11 hinders C‐MYC‐induced SKP2 from binding to the C‐MYC MB2 domain for ubiquitination, thereby stabilizing C‐MYC to drive tumor progression.
Li Ding +12 more
wiley +1 more source
Brain and Behavior, Volume 12, Issue 12, December 2022., 2022 Abstract Background There are few studies about the relationship between dietary patterns and aggression. The aim of this study was to assess the relationship between the main dietary patterns and aggression scores among adolescent girls in Iran. Methods This cross‐sectional study was conducted on 670 adolescent girls.
Mahsa Malekahmadi +8 more
wiley +1 more source