Results 121 to 130 of about 19,491,478 (363)

Underreporting of Hepatitis E virus infection in Tanzania: a systematic review

South Sudan Medical Journal, 2020
Introduction: Hepatitis E virus (HEV) frequently causes acute hepatitis with water-borne outbreaks in endemic areas. Updated evidence is required in Tanzania to inform the policymakers and identify research gaps.
Semvua B. Kilonzo , Daniel W. Gunda , Elichilia R. Shao , Fatma A. Bakshi   +3 more
doaj  

PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β‐TrCP‐Mediated IFNAR1 Degradation

Advanced Science, EarlyView.
Hijacking Host Kinase PIM1: A β‐Coronavirus (OC43) strategy to degrade IFNAR1 and evade antiviral immunity. Human β‐coronaviruses (OC43) exploit the proto‐oncoprotein PIM1 kinase to sabotage innate immunity. Viral RNA/proteins upregulate PIM1, which phosphorylates E3 ligase β‐TrCP1.
Qianya Wan, Lin Zhu, Cien Chen, Li Zhong, Houying Leung, Wei Li, Chang Xu, Xi Yao, Huan Hu, Mandi Wu, Yuxin Hou, Hin Chu, Yiran Wang, Sheng Chen, Mingyu Pan, Zongwei Cai, Ming‐liang He   +16 more
wiley   +1 more source

Occurrence of e antigen in acute hepatitis B. [PDF]

, 1977
Patricia E. Gibson, K Ruparella
openalex   +1 more source

Hepatic ENTPD5 Is Critical for Maintaining Metabolic Homeostasis and Promoting Brown Adipose Tissue Thermogenesis

Advanced Science, EarlyView.
ENTPD5‐mediated conversion of extracellular adenosine triphosphate to ADP of hepatocytes is critical for maintaining hepatic glucose/lipid metabolism and promoting brown adipose tissue thermogenesis via the inhibition of adrenomedullin expression and secretion.
Rufeng Ma, Song Hou, Rui Xiang, Wenjun Liu, Xin Li, Yujing Chi, Ming Xu, Haochen Yao, Jing Li, Jichun Yang   +9 more
wiley   +1 more source

Anti-e and vertical transmission of hepatitis B surface antigen. [PDF]

, 1977
A.K.R. Chaudhuri, E. A. C. Follett, C. J. Burrell   +2 more
openalex   +1 more source

The NSP5, ORF6 and NSP13 of SARS‐CoV‐2 Cooperate to Modulate Inflammatory Cell Death Activation

Advanced Science, EarlyView.
ZBP1 is capable of initiating a large cell death complex to induce programmed cell death during SARS‐CoV‐2 infection. However, SARS‐CoV‐2 can inhibit the activation of ZBP1‐mediated cell death by targeting key components of this complex. This suppression of ZBP1‐mediated cell death may account for the increased mortality observed in patients co ...
Huan Wang, Mengdi Liang, Jing Zhang, Hua Tong, Fenfen Zhang, Ying Liu, Pui Wang, Mengmeng Chang, Fei Han, Siwen Liu, Yongping Lin, Wenjun Song, Rajendra Karki, Peihui Wang, Honglin Chen, Yang Liu, Min Zheng   +16 more
wiley   +1 more source

GHSR‐Foxo1 Signaling in Macrophages Promotes Liver Fibrosis via Inflammatory Response and Hepatic Stellate Cell Activation

Advanced Science, EarlyView.
Macrophage GHSR‐Foxo1 axis regulates CCl4‐induced liver fibrosis by promoting inflammation and TGF‐β1‐mediated HSC activation. GHSR activates PKA‐dependent phosphorylation of Foxo1 at serine 273, promoting macrophage pro‐inflammatory polarization to enhance the production of pro‐inflammatory cytokines that damage hepatocytes, thereby inducing liver ...
Da Mi Kim, Quan Pan, Zeyu Liu, Weiqi Ai, Hye Won Han, Sakhila K. Banu, Robert Y.L. Tsai, Gus A. Wright, Shaodong Guo, Yuxiang Sun   +9 more
wiley   +1 more source

Performance evaluation of new automated VIDAS anti-HEV immunoassay tests

Journal of Virus Eradication, 2018
Florence Abravanel, Nadège Goutagny, Sébastien Lhomme, Corinne Perret, Mathilde Chenet, Françoise Vischi, Alexandre Aversenq, Sandrine Bourg, Aude Chapel, Nathalie Dehainault, Laurence Mercier, Françoise Luciani, Catherine Pothion, Emile Eichenlaub, Thomas Bénet, Xinxin Zhang, Pierre Roques, Jean-Marc Dugua, Jacques Izopet   +18 more
doaj   +1 more source

SIRT6 Lysine‐Demyristoylates ATF2 to Ameliorate Vascular Injury via PRKCD/VE‐Cadherin Pathway Regulating Vascular Endothelial Barrier

Advanced Science, EarlyView.
A novel modified SIRT6 variant (dSIRT6) H133Y‐mediated enrichment technique unmasks 15 new human lysine‐myristoylated proteins. Notably, Sirtuin 6 (SIRT6) demyristoylation of activating transcription factor 2 (ATF2) at K296 orchestrates its nucleoplasmic translocation.
Runyang Feng, Zheyan Fang, Shuang Zhao, You‐en Zhang, Na Wu, Zhenyang Guo, Xin Zhong, Bixuan Jiang, Hongfei Xu, Hangnan Hong, Zhentao Zhang, Mukaddas Abdurahman, Xueting Yu, Jilong Geng, Xiansu Nie, Supuya Abuduwahapi, Dong Huang, Gang Zhao, Wenbin Zhang, Hao Lu, Li Shen, Xin Zhao, Zhaoyang Chen, Junjie Guo, Hongchao Zheng, Yue He, Sanwu Wu, Jiayin Peng, Jiawen Song, Xiao Wang, Haomin Li, Yuli Huang, Shengying Qin, Haojie Lu, Xiangdong Wang, Jianguo Zhao, Lei Huang, Yun Zhao, Peng Li, Junbo Ge, Hua Li   +40 more
wiley   +1 more source

Advancements in DNA‐Driven Precision Modulation of Cell Surface Receptor for Programmable Cellular Functions

Advanced Science, EarlyView.
DNA‐Based Genetic and Non‐Genetic Tools for Receptor Engineering. This review highlights recent advances in DNA‐based strategies for receptor engineering, including genetic approaches like domain fusion and site‐directed mutagenesis, as well as non‐genetic methods using functional nucleic acids, DNA nanostructures, and dynamic DNA reactions.
Hexin Nan, Ming Cai, Yiyu Wang, Hong‐Hui Wang, Zhou Nie   +4 more
wiley   +1 more source