T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study [PDF]
, 2018 Background/Aims: The hepatitis C virus (HCV) infection is important cause of chronic hepatitis. Liver biopsy is considered the gold standard for assessment of fibrosis but this procedure is an invasive procedure.
Akhan, S. +34 more
core +1 more source
Advanced Science, EarlyView.In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu +9 more
wiley +1 more source
Hepatitis C virus related cirrhosis decreased as indication to liver transplantation since the introduction of direct-acting antivirals: A single-center study [PDF]
, 2018 AIM: To evaluate waiting list (WL) registration and liver transplantation (LT) rates in patients with hepatitis C virus (HCV)-related cirrhosis since the introduction of direct-acting antivirals (DAAs).
Angeli, Paolo +10 more
core +1 more source
Hepatitis aguda por virus E con características de autoinmunidad. Reporte de un caso [PDF]
, 2021 María Laura Garrido +3 more
openalex +1 more source
Designing Scalable Mechano‐Virucidal Nanostructured Acrylic Surfaces for Enhanced Viral Inactivation
Advanced Science, EarlyView.Can a surface be designed to physically break viruses? This study explores how nanoscale geometry—specifically the spacing of tiny pillars—can determine whether viruses remain intact or rupture. Using flexible acrylic and a scalable fabrication process, the authors develop nanopillared, transparent surfaces that show strong antiviral activity without ...
Samson W. L. Mah +14 more
wiley +1 more source
Hepatitis E in a food handler – a rapid risk assessment to guide the public health response
Western Pacific Surveillance and Response, 2014 Objective: The Australian Capital Territory Health Directorate was notified of a food handler with hepatitis E virus (HEV) infection. To guide the public health response, a rapid risk assessment was undertaken to determine the risk of transmission of HEV
Ranil Appuhamy +4 more
doaj +1 more source
Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics
Advanced Science, EarlyView.This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu +6 more
wiley +1 more source
[Advances in hepatitis E epidemiology].
, 2023 Xiaoyi Yang, Qiongyi He, Lin Wang
openalex +2 more sources