Results 251 to 260 of about 641,799 (359)

The In Vitro-Synthesized RNA from a cDNA Clone of Hepatitis E Virus Is Infectious [PDF]

, 2000
Subrat Kumar Panda, Israr-ul H. Ansari, Hemlata Durgapal, Shipra Agrawal, Shahid Jameel   +4 more
openalex   +1 more source

Development and Recent Advances in SLIPT‐PM: A Chemogenetic Platform for Manipulating Signaling at the Plasma Membrane

ChemBioChem, Accepted Article.
Upon cell stimulation, mammalian cells activate various signaling proteins and lipids by recruiting their upstream regulators to the inner leaflet of the plasma membrane (PM), which in turn determines their cellular response. Therefore, artificially inducing protein translocation to the PM is an effective strategy for dissecting cell signaling networks
Shuya Ohira, Akinobu Nakamura, Kenta Terai, Shinya Tsukiji   +3 more
wiley   +1 more source

Enhanced hepatitis E virus infection of polarised hepatocytes in vitro. [PDF]

Sci Rep
Brown HM, Marlet J, León-Janampa N, Brand D, Fletcher NF.   +4 more
europepmc   +1 more source

Harnessing Viral Proteases for Cellular and Molecular Engineering

Chemistry–Methods, EarlyView.
Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui, Tien‐Hung Lan, Yubin Zhou   +2 more
wiley   +1 more source

Correction: Therapeutic treatment of hepatitis E virus infection in pigs with a neutralizing monoclonal antibody. [PDF]

Sci Rep
Hrabal I, Aliabadi E, Reiche S, Weber S, Holicki CM, Schmid L, Fast C, Schröder C, Gutjahr B, Behrendt P, Groschup MH, Eiden M.   +11 more
europepmc   +1 more source

In VitroInfection and Replication of Hepatitis E Virus in Primary Cynomolgus Macaque Hepatocytes

, 1997
Albert W. Tam, Richard White, Patrice O. Yarbough, Brendan Murphy, C. Patrick McAtee, Robert E. Lanford, Thomas R. Fuerst   +6 more
openalex   +1 more source

Evaluation of Potential Effects of CYP3A Inhibition and CYP3A Induction on the Pharmacokinetics of Fruquintinib in Healthy Subjects

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Cytochrome P450 (CYP) 3A plays a significant role in fruquintinib metabolism in vitro. This 2‐part, 2‐period fixed‐sequence study investigated the impact of CYP3A inhibition (itraconazole) and CYP3A induction (rifampin) on the pharmacokinetics (PK) of fruquintinib and M11, its main metabolite.
Martha Gonzalez, Zhao Yang, William R Schelman, Xiaofei Zhou, Neeraj Gupta, Caly Chien   +5 more
wiley   +1 more source

Zoonotic rat hepatitis E virus infection in pigs: farm prevalence and public health relevance. [PDF]

Porcine Health Manag
Caballero-Gómez J, García-Bocanegra I, Cano-Terriza D, Casares-Jiménez M, Jiménez-Ruiz S, Risalde MA, Ríos-Muñoz L, Rivero-Juárez A, Rivero A.   +8 more
europepmc   +1 more source

Effect of Mild to Moderate Hepatic Impairment on Valemetostat Pharmacokinetics: An Open‐Label, Phase I Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Valemetostat tosylate (valemetostat) is a dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1, approved in Japan for the treatment of relapsed/refractory peripheral T‐cell lymphoma and adult T‐cell leukemia/lymphoma. This Phase I, open‐label study evaluated the pharmacokinetics and safety of a single 50‐mg oral dose of valemetostat in
Masaya Tachibana, Thuy Vu Craveiro, Thomas C. Marbury, Samuel Oberstein, George J. Atiee, Ben Tao, Takako Shimizu, Yvonne Lau, Malaz A. Abutarif   +8 more
wiley   +1 more source

Cost-Effectiveness Analysis of Hepatitis E Vaccination Strategies for Swine Workers. [PDF]

Transbound Emerg Dis
Wang F, Zhou L, Lu Y.
europepmc   +1 more source