Results 161 to 170 of about 271,461 (267)

Lipid Profile Differences in HIV‐Infected Populations With Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Systematic Review and Meta‐Analysis

Chronic Diseases and Translational Medicine, EarlyView.
PRISMA study flow diagram. ABSTRACT Introduction Advances in HIV management have transformed HIV into a chronic condition, resulting in improved prognosis and increased survival among people living with HIV (PLWH). Traditional risk factors for metabolic dysfunction‐associated steatotic liver disease (MASLD)—including dyslipidemia—are prevalent in PLWH.
Yovita Hartantri, Sherly Lawrensia, Steven Yulius Usman, Nenny Agustanti, Rudi Wisaksana, Nanny Natalia Mulyani Soetedjo, Bachti Alisjahbana   +6 more
wiley   +1 more source

Unveiling hepatitis E virus diversity in Sudan's internally displaced populations: a molecular epidemiology approach. [PDF]

Trop Med Health
Osman HA, Bakr WMK, Hashish MH, Elkhidir IM, Bedri S, Oyola SO, Norder H, Abd El-Wahab EW.   +7 more
europepmc   +1 more source

Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis

, 2021
José Carlos Rodrigues Nascimento, Lianna Cavalcante Pereira, Juliana Magalhães da Cunha Rêgo, Ronaldo Pereira Dias, Paulo Goberlânio B Silva, Silvio Alencar C Sobrinho, Gustavo Coelho, Ivelise Regina Canito Brasil, Edmilson Ferreira de Oliveira-Filho, James S. Owen, Pierluigi Toniutto, Reinaldo B. Oriá   +11 more
openalex   +1 more source

Conformational Trajectory of the Molecular Chameleon Grazoprevir from Formulation to Target‐Bound

Chemistry – A European Journal, EarlyView.
ABSTRACT Macrocycles represent a promising class of beyond‐rule‐of‐5 (bRo5) therapeutics, capable of targeting proteins traditionally considered undruggable by conventional small molecules. Macrocycles exhibit intrinsic flexibility and often display a “chameleon‐like” ability to adapt to their environment, thereby enhancing their oral bioavailability ...
Lianne H. E. Wieske, Guanhong Bu, Máté Erdélyi, Jan Kihlberg, Tamir Gonen, Emma Rova Danelius   +5 more
wiley   +1 more source

Zoonotic hepatitis E virus spreads through environmental routes in pig herds - A phylodynamic analysis. [PDF]

PLoS Pathog
Meester M, Valenzuela Agüí C, Tobias TJ, Hakze van der Honing RW, Guinat C, Bouwknegt M, du Plessis L, Fischer EAJ, Spaninks M, Stadler T, van der Poel WHM, Stegeman A.   +11 more
europepmc   +1 more source

Prevalences of hepatitis A, B, C and E viruses in Behçet's disease [PDF]

, 1999
Kenan Aksu, Yasemin Kabasakal, A. Arzu Sayiner, Gökhan Keser, Fahrettin Öksel, A Bilgiç, G. Gümüşdi̇ş, Eker Doğanavşargil   +7 more
openalex   +1 more source

A Phase 1, Randomized, Open‐Label, Parallel Group Study to Evaluate the Relative Bioavailability and Safety of Subcutaneous Bepirovirsen when Delivered from a Vial or Prefilled Syringe Fitted with a Safety Syringe Device in Healthy Adult Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bepirovirsen, an antisense oligonucleotide in development for the treatment of chronic hepatitis B virus (HBV) infection, is administered from glass vials as a subcutaneous (SC) injection by healthcare professionals (HCPs). A ready‐to‐use prefilled syringe (PFS) assembled with a safety syringe device (SSD) has been developed to make ...
Amir S. Youssef, Poonam Shah, Maxwell Hu, Helene Plein, Abhishek Roy, Ravi Sharma, Sarah Mole, Magdalena Blazejczyk, Wendy Cross, Brian Spears, Samuel Pak, Rejbinder Kaur, Robert Elston, Dickens Theodore, Marjan Hezareh, Ahmed Nader   +15 more
wiley   +1 more source

A Rare Case of Triple Infection with Leptospira, Hepatitis A Virus, and Hepatitis E Virus. [PDF]

Reports (MDPI)
Petrakis V, Babaka N, Panopoulou M, Papazoglou D, Panagopoulos P.   +4 more
europepmc   +1 more source

Seroprevalence of Hepatitis E Virus Infection Among People Living With HIV in the Central African Republic

, 2018
Ornella Anne Demi Sibiro, Alexandre Manirakiza, Narcisse Komas   +2 more
openalex   +1 more source

Effects of High‐ and Low‐Fat Meals on the Bioavailability and Pharmacokinetics of Votoplam, a HTT Gene Splicing Modifier

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Votoplam is a novel, orally bioavailable, small molecule HTT gene splicing modifier that is being developed for the treatment of Huntington's disease. This was a single dose, open‐label, two‐period, crossover food effect study that evaluated the effect of high‐ and low‐fat meals on 20 mg votoplam in healthy participants. There was a washout of
Lucy Lee, Amy‐Lee Richards, Nageswara Reddy, Brian Beers, Lee Golden, Ronald Kong   +5 more
wiley   +1 more source