Results 71 to 80 of about 21,170 (204)

Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells [PDF]

, 2018
Paclitaxel is a treatment option for advanced or metastatic bladder cancer after the failure of first-line cisplatin and gemcitabine, although resistance limits its clinical benefits.
Flores, M. Luz, Gasca Bellido, Jessica María, Japón Rodríguez, Miguel Ángel, Jiménez Guerrero, Rocío, Medina, Rafael, Pérez Valderrama, Begoña, Romero Portillo, Francisco, Tortolero García, María Dolores   +7 more
core   +1 more source

The transformative potential of artificial intelligence in pediatric medicine: Current applications, methodological challenges, and future directions

Pediatric Investigation, EarlyView.
Artificial intelligence (AI) offers transformative potential for paediatric diagnosis and treatment, yet implementation faces unique challenges, including data scarcity, algorithmic bias, and children's developmental physiology. This review examines current applications and charts a path toward transparent, equitable, and trustworthy AI in child health.
Ruisong Wang, Xiaoman Ding, Wanyue Zhang, Tieliu Shi   +3 more
wiley   +1 more source

Hepatoblastoma associated with trisomy 18

Journal of Pediatric Surgery Case Reports, 2020
There is currently no consensus regarding the treatment strategy for malignant tumors with trisomy 18 because of the high mortality rate of this genetic disorder. In this study, we reported five cases of hepatoblastoma associated with trisomy 18.
Naruhiko Murase, Kenitiro Kaneko, Asahito Hama, Nao Yoshida, Hirotoshi Sakaguchi, Kosuke Chiba, Makoto Oshiro   +6 more
doaj   +1 more source

Liver Resection for Primary Hepatic Neoplasms. [PDF]

, 1988
Subtotal hepatic resection was performed in 356 patients; 87 had primary hepatic malignancies, 108 had metastatic tumors, and 161 had benign lesions including 8 traumatic injuries. The global mortality was 4.2%.
C. Couinaud, J. L. Lortat-Jacob, J. R. Craig, L. Abel, M. M. Berman, N. A. Goldsmith, O. H. Wangensteen, R. W. Raven, S. Iwatsuki, T. E. Starzl, T. E. Starzl, T. E. Starzl, T. E. Starzl, T. E. Starzl, Th. E. Starzl, W. Wendel, Y. G. Adam   +16 more
core   +1 more source

Comparison of ultrasonographic features between two types of hepatic echinococcosis and hepatoblastoma in children

Frontiers in Pediatrics
IntroductionThe prevalence of hepatic alveolar echinococcosis (AE) and cystic echinococcosis (CE) is notably high among children in western China, with the mortality rate for untreated children potentially reaching up to 90%. Meanwhile, hepatoblastoma is
Yi Tao, Hanqing Kong, Jiawu Li, Zhizhi Tan, Jun Wang, Yan Luo   +5 more
doaj   +1 more source

NRAS and KRAS polymorphisms are not associated with hepatoblastoma susceptibility in Chinese children

Experimental Hematology & Oncology, 2019
Background Hepatoblastoma is the most common hepatic malignancy in children, accounting for approximately 80% of all childhood liver tumors. KRAS and NRAS, members of the RAS gene family, are closely linked to tumorigenesis, and are frequently mutated in
Tianyou Yang, Yang Wen, Jiahao Li, Tianbao Tan, Jiliang Yang, Jing Pan, Chao Hu, Yuxiao Yao, Jiao Zhang, Yijuan Xin, Suhong Li, Huimin Xia, Jing He, Yan Zou   +13 more
doaj   +1 more source

Simpson-Golabi-Behmel syndrome types I and II [PDF]

, 2014
Simpson-Golabi-Behmel syndrome (SGBS) is a rare overgrowth syndrome clinically characterized by multiple congenital abnormalities, pre/postnatal overgrowth, distinctive craniofacial features, macrocephaly, and organomegaly.
Fernando Santos, Jair Tenorio, Julián Nevado, Pablo Lapunzina, Pedro Arias, Sixto García-Miñaur, Víctor Martínez-Glez   +6 more
core   +1 more source

Interventional oncology in children: Where are we now?

Journal of Medical Imaging and Radiation Oncology, EarlyView.
Abstract Paediatric Interventional Oncology (IO) lags behind adult IO due to a scarcity of specific outcome data. The suboptimal way to evolve this field is relying heavily on adult experiences. The distinct tumour types prevalent in children, such as extracranial germ cell tumours, sarcomas, and neuroblastoma, differ strongly from those found in ...
Premal Amrishkumar Patel, Fernando Gómez Muñoz   +1 more
wiley   +1 more source

A Personalised Vaccination Program Based on Immune Reconstitution in Paediatric Cancer Survivors

Acta Paediatrica, EarlyView.
ABSTRACT Aims Paediatric cancer survivors often experience treatment‐induced immunosuppression, requiring post‐treatment revaccination. However, immune recovery timelines vary, and current revaccination guidelines, largely based on data of varied quality derived from studies on acute‐lymphoblastic‐leukaemia (ALL), may not be applicable across all ...
Menucha Jurkowicz, Raz Somech, Dan Dominissini, Nathan Keller, Efrat Dresner, Michal Paret, Gilad Sherman, Guy Katzenellenbogen, Elina Gelman, Keren Asraf, Ram Doolman, Atar Lev, Amos J. Simon, Helly Vernitsky, Assaf Barg, Hana Golan, Amos Toren, Michal Stein   +17 more
wiley   +1 more source

Integrating the diagnosis of childhood malignancies [PDF]

, 2008
Significant progress has been made in understanding the molecular basis of pediatric malignancies. Mechanisms of pediatric acute leukemia induction include hyperdiploidy, aberrant expression of proto-oncogenes, and activation of transcription factors or ...
Lopez-Terrada, Dolores
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