Results 131 to 140 of about 690,479 (320)

Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment‐Integrated Organ‐On‐Chip Models

open access: yesAdvanced Therapeutics, EarlyView.
Emerging microphysiological systems reproduce the spatial, biochemical, and cellular complexity of the tumor microenvironment, surpassing 2D cultures and murine models. By integrating patient‐derived tumors, perfusable vasculature, and immune trafficking, these organ‐on‐chip platforms reveal mechanisms of immune evasion, predict therapeutic responses ...
Fabiana Moresi   +5 more
wiley   +1 more source

Genetic Engineering Methods in Primary T Cells

open access: yesAdvanced Therapeutics, EarlyView.
Primary T cells can be engineered to confer them with novel therapeutic functions, allowing them to treat a variety of conditions. Genetic engineering can be either stable or transient, aiming to either express or inhibit a target gene. This review discusses the various genetic engineering tools available as well as their characteristics and ...
Anthony Youssef, Hui‐Shan Li
wiley   +1 more source

Hepatocellular carcinoma with the carcinoid syndrome [PDF]

open access: bronze, 1971
Aron Primack   +5 more
openalex   +1 more source

Anisotropic Surface Microrollers for Endovascular Navigation: A Computational Analysis with a Case Study in Hepatic Perfusion

open access: yesAdvanced Theory and Simulations, EarlyView.
Computational fluid dynamics analyses assess the upstream locomotion performance of anisotropic microrollers with varying height‐to‐width ratios. Observing their successful upstream locomotion in veins, their performance in hepatic circulation is investigated for treating primary liver cancer.
Burak Arslan   +8 more
wiley   +1 more source

Autophagy-related long non-coding RNA MIR210HG plays a therapeutic role in hepatocellular carcinoma

open access: yesDiscover Oncology
Objective This study aimed to investigate the role of the autophagy-related long noncoding RNA (lncRNA) MIR210HG in hepatocellular carcinoma and its potential as a therapeutic target.
Chaoqun Zhang   +6 more
doaj   +1 more source

Immunohistochemical angiogenic biomarkers in hepatocellular carcinoma and cirrhosis: correlation with pathological features

open access: yesClinics
OBJECTIVE To investigate immunohistochemical markers of angiogenesis and their association with pathological prognostic features in hepatocellular carcinoma and cirrhotic liver.
Osmar Damasceno Ribeiro   +2 more
doaj   +1 more source

SMYD3 Promotes Immune Evasion in Clear Cell Renal Cell Carcinoma via SREBP1‐Mediated Transactivation of CD47

open access: yesAdvanced Science, EarlyView.
Cancer cell‐intrinsic SMYD3 orchestrates an immunosuppressive microenvironment and impairs the response to PD‐1 blockade by reprogramming immune cells landscape in the tumor microenvironment of clear cell renal cell carcinoma (ccRCC). The immunomodulatory function of SMYD3 is mediated via the SREBP1/CD47 pathway.
Zhengfang Liu   +14 more
wiley   +1 more source

Paediatric hepatoblastoma and hepatocellular carcinoma: retrospective study. [PDF]

open access: yes, 2002
OBJECTIVES: To compare and contrast clinical characteristics and outcomes of hepatoblastoma or hepatocellular carcinoma in paediatric patients. DESIGN: Retrospective study. SETTING: University teaching hospital, Hong Kong.
Chan, GC   +5 more
core  

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