Results 211 to 220 of about 200,012 (263)
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Biochemical Society Transactions, 2000
Hepatocyte couplets, by retaining functional and morphological polarity similar to that of hepatocytes in situ, are a valuable in vitro model to study mechanisms of bile secretion, cholestasis and hepatocellular injury. They have been useful in studies of the hormonal control of bile formation and are suitable for morphological studies.
R, Coleman, M G, Roma
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Hepatocyte couplets, by retaining functional and morphological polarity similar to that of hepatocytes in situ, are a valuable in vitro model to study mechanisms of bile secretion, cholestasis and hepatocellular injury. They have been useful in studies of the hormonal control of bile formation and are suitable for morphological studies.
R, Coleman, M G, Roma
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Comprehensive Physiology, 2013
Abstract Hepatocytes, like other epithelia, are situated at the interface between the organism's exterior and the underlying internal milieu and organize the vectorial exchange of macromolecules between these two spaces. To mediate this function, epithelial cells, including hepatocytes, are polarized with distinct
Aleksandr, Treyer, Anne, Müsch
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Abstract Hepatocytes, like other epithelia, are situated at the interface between the organism's exterior and the underlying internal milieu and organize the vectorial exchange of macromolecules between these two spaces. To mediate this function, epithelial cells, including hepatocytes, are polarized with distinct
Aleksandr, Treyer, Anne, Müsch
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Artificial Cells, Blood Substitutes, and Biotechnology, 1999
Homogenized rat hepatocytes, whole hepatocytes and encapsulated hepatocytes were incubated with bilirubin and UDP-glucuronic acid to test their ability to form bilirubin conjugates. Bilirubin monoconjugated and diconjugated were detected in all the three preparations by HPLC analysis.
S, Bruni, T M, Chang
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Homogenized rat hepatocytes, whole hepatocytes and encapsulated hepatocytes were incubated with bilirubin and UDP-glucuronic acid to test their ability to form bilirubin conjugates. Bilirubin monoconjugated and diconjugated were detected in all the three preparations by HPLC analysis.
S, Bruni, T M, Chang
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2006
Isolated hepatocytes are a physiologically relevant in vitro model exhibiting intact subcellular organelles, xenobiotic transport, and integrated phase I and phase II biotransformation. They represent the "gold standard" for investigating xenobiotic biotransformation and metabolic bioactivation.
Elaut, Greetje +6 more
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Isolated hepatocytes are a physiologically relevant in vitro model exhibiting intact subcellular organelles, xenobiotic transport, and integrated phase I and phase II biotransformation. They represent the "gold standard" for investigating xenobiotic biotransformation and metabolic bioactivation.
Elaut, Greetje +6 more
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Microencapsulating Hepatocytes
Transplantation Proceedings, 2005Because standardization of the cell microencapsulation procedure has not yet been achieved, we performed hepatocyte microencapsulation using alginate (ALG)-poly-l-lysine (PLL)-ALG (APA) polymer.Hepatocytes were microencapsulated using a binozzle air-jet droplet generator.
Y, Gao +4 more
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Current Protocols in Toxicology, 2001
AbstractThis unit describes a process for isolation of intact, viable hepatocytes for use in integrated drug metabolism studies. Isolated hepatocytes are increasingly being used as a biological system for studying the in vitro metabolism of xenobiotics.
D R, Mudra, A, Parkinson
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AbstractThis unit describes a process for isolation of intact, viable hepatocytes for use in integrated drug metabolism studies. Isolated hepatocytes are increasingly being used as a biological system for studying the in vitro metabolism of xenobiotics.
D R, Mudra, A, Parkinson
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Hepatocyte Xenotransplantation
2012Xenotransplantation of hepatocytes is a future promise to treat liver diseases when there is a formal indication for transplantation. In this chapter, we describe techniques for hepatocyte xenotransplantation. The process was divided into three main steps: hepatocyte isolation, transplantation, and identification of donor cells in the recipient.
Katia R F, Lima-Quaresma +4 more
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Metabolism of Asialotranscortin by Hepatocytes and Cortisol Binding to Hepatocytes
Endocrine Research Communications, 1981Binding and catabolism of iodinated human transcortin and asialotranscortin were studied in isolated rat hepatocytes. Human transcortin binding to hepatocytes was very low (less than 3%) while 40-60% of the asialotranscortin bound to the hepatocytes. Asialofetuin inhibited asialotranscortin binding to hepatocytes, producing 50% inhibition of binding at
K L, Hossner, R B, Billiar
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2009
Apoptosis has been documented as a frequent hurdle phenomenon that occurs in human hepatocytes during isolation, storage, infusion and after engraftment within the recipient liver parenchyma. Apoptosis is an active form of cell death that involves programmed cellular machineries leading to a progressive self-destruction of the cell.
Mustapha, Najimi +2 more
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Apoptosis has been documented as a frequent hurdle phenomenon that occurs in human hepatocytes during isolation, storage, infusion and after engraftment within the recipient liver parenchyma. Apoptosis is an active form of cell death that involves programmed cellular machineries leading to a progressive self-destruction of the cell.
Mustapha, Najimi +2 more
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Hepatocytes: The powerhouse of biotransformation
The International Journal of Biochemistry & Cell Biology, 2012Liver is the most important organ involved in biotransformation of xenobiotics. Within the main organisational unit, the hepatocyte, is an assembly of enzymes commonly classified as phase I and phase II enzymes. The phase I enzymes principally cytochrome P450 catalyse both oxidative and reductive reactions of a bewildering number of xenobiotics.
Danielle K, Sevior +2 more
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