Results 61 to 70 of about 177,432 (192)

Brain susceptibility changes in neurologically asymptomatic pediatric patients with Wilson's disease: evaluation with quantitative susceptibility mapping

, 2018
Background: Wilson's disease (WD) is a copper metabolism disorder that causes hepatolenticular degeneration.
Selim Doganay, Duran Arslan, Sibel Saracoglu, Gonca Koc, Hakan Gumus, Kazim Gumus, GÜMÜŞ, Hakan, SARAÇOĞLU, Sibel, GUMUS, Kazim, Ayse Kacar Bayram, BAYRAM, Ayse Kacar, Doganay, Selim, ARSLAN, Duran, Koc, Gonca   +13 more
core   +1 more source

DataSheet1_Protective Mechanism of Gandou Decoction in a Copper-Laden Hepatolenticular Degeneration Model: In Vitro Pharmacology and Cell Metabolomics.pdf

, 2022
Gandou decoction (GDD) is a classic prescription for the treatment of hepatolenticular degeneration (HLD) in China; however, the liver-protecting mechanism of this prescription needs further evaluation.
Shijian Cao (9573488), Na Wang (193263), Huan Wu (617276), Mengnan Nian (12278180), Peng Wu (210686), An Zhou (190912), Hongfei Wu (470334), Fengxia Yin (12278177), Wenchen Zhao (1328967)   +8 more
core   +1 more source

An Open‐Label Phase 1b Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of ANX005 in Patients with Huntington's Disease

Movement Disorders, Volume 41, Issue 6, Page 1492-1501, June 2026.
Complement activation is implicated in Huntington's disease; ANX005 is a potent inhibitor of component C1q. ANX005 exhibited a generally manageable safety profile with rapid reduction in C1q in the cerebrospinal fluid. Functional ability on composite Unified Huntington's Disease Rating Scale and total functional capacity was maintained, with potential ...
Rajeev Kumar, Pinky Agarwal, Karen Anderson, Daniel Claassen, Marissa Dean, Andrew Duker, Burton Scott, Benjamin Hoehn, Ann Mongan, Ping Lin, Ellen Cahir‐McFarland, Lori Taylor, Glenn Morrison, Ted Yednock, Sanjay Keswani, Henk‐Andre Kroon   +15 more
wiley   +1 more source

Hepatolenticular degeneration with hidden pathology of liver: Case report

Анналы клинической и экспериментальной неврологии, 2017
A case of hepatolenticular degeneration (HLD) in a 27-year-old patient is reported. The earliest signs of the disease were observed as isolated psychoneurological symptoms (mainly as polymorphic extrapyramidal and cerebellar disorders). Neither clinical,
Nadezhda V. Vyalova, Denis S. Doloka, Tatyana N. Proskokova, Aleksandr M. Khelimskiy   +3 more
doaj   +1 more source

Development and Validation of a Brief Fall Questionnaire (FALL‐HD) for Patients with Huntington's Disease

Movement Disorders Clinical Practice, Volume 13, Issue 4, Page 949-955, April 2026.
ABSTRACT Background Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a mutation in the huntingtin gene on chromosome 4, leading to progressive cognitive decline, motor impairment, and functional disability. Falls represent the leading cause of nursing home placement in HD.
Japleen Kaur, Deng‐Yuan Liou, Krisha Bagga, Nadeen Youhanan, Andrew Hall, Paul E. Gilbert, Daniel J. Goble, Jody Corey‐Bloom   +7 more
wiley   +1 more source

Mapping Regional Brain Aging in Huntington's Disease Using Structural Magnetic Resonance Imaging and Machine Learning

Movement Disorders, Volume 41, Issue 4, Page 881-888, April 2026.
Abstract Background Huntington's disease (HD) is a progressive neurodegenerative disorder. Models of brain biological age have shown evidence of accelerated aging relative to chronological age, but they typically rely on a single whole‐brain measure. While studies in other neurodegenerative diseases suggest region‐specific brain age models can provide ...
Mohsen Ghofrani‐Jahromi, Yalda Amirmoezzi, Pubu M. Abeyasinghe, Govinda R. Poudel, Adeel Razi, Jane S. Paulsen, Nicola Z. Hobbs, Rachael I. Scahill, Sarah J. Tabrizi, Nellie Georgiou‐Karistianis, Susmita Saha   +10 more
wiley   +1 more source

Bioinformatics and Immunohistochemistry Reveal the Diagnostic and Mechanistic Role of the Cuproptosis‐Related Genes SMOC2/THY1 in Liver Fibrosis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT Cuproptosis, a newly identified form of programmed cell death, inhibits liver fibrosis in hepatic stellate cells. However, how cuproptosis influences liver fibrosis in other cells remains to be determined. We aimed to develop a diagnostic model for cuproptosis and to further investigate its role in liver fibrosis.
Ranyan Gao, Hongliang Chen, Jiaxin Wang, Lingyi Xu, Fengchun Li, Xinyu Jiang, Xinyu Geng, Ning Li, Ram Prasad Chaulagain, Babalola Deborah Oluwaseun, Wanwei Li, Shizhu Jin   +11 more
wiley   +1 more source

Expanding the Phenotype of PARK‐PRKN to Spastic Paraplegia: A Report of Two Cases

Movement Disorders Clinical Practice, Volume 13, Issue 10, Page 2626-2628, October 2026.
Nicolas Geoffre, Thomas Ollivier, Guillaume Baille, Luc Defebvre, Vincent Huin, Eugenie Mutez   +5 more
wiley   +1 more source

Huntington's Disease and Huntington's Disease‐like 2 (HDL2) in Martinique

Movement Disorders Clinical Practice, Volume 13, Issue 3, Page 673-682, March 2026.
ABSTRACT Background Huntington's Disease‐like 2 (HDL2), caused by a CAG repeat expansion in JPH3, closely resembles HD. All reported HDL2 patients to date have some African ancestry. While both disorders exist in the Caribbean, their relative frequency and clinical characteristics remain largely unknown.
Ignacio Antolin‐Sanfeliz, Anna‐Gaelle Giguet‐Valard, Sophie Duclos, Cécile Cazeneuve, Chloé Angelini, Aïssatou Signaté, Russell L. Margolis, Cyril Goizet, Rémi Bellance   +8 more
wiley   +1 more source

Genetic variants underlying precancerous conditions of hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 3, Page 488-502, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for 80% of cases worldwide. While chronic hepatitis B and C infections remain primary risk factors, emerging evidence highlights the increasing contributions of metabolic dysfunction‐associated steatotic liver disease (MASLD) and alcohol‐associated liver disease
Jonathan Jaime G. Guerrero, Paolo C. Encarnacion, Mark Angelo S. del Rosario, Matthew Aldren S. Ora, Jiayan Zhou, Kin Israel Notarte, Wan‐Chun Li, Ching‐Wen Chang   +7 more
wiley   +1 more source