Lewis Acid-Catalyzed 1,3-Dipolar Cycloaddition of Bicyclobutanes with Isatogens: Access to Tetracyclic 2‑Oxa-3-azabicyclo[3.1.1]heptanes [PDF]
JACS AuThe ’escape from flatland’ concept has gained significant traction in modern drug discovery, emphasizing the importance of three-dimensional molecular architectures, which serve as saturated bioisosteres of benzenoids. Bicyclo[1.1.0]butanes (BCBs), known
Shiksha Deswal +3 more
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Organophotoredox-Catalyzed Stereoselective Synthesis of Bicyclo[3.2.0]heptanes via [2+2] Photocycloaddition [PDF]
MoleculesThe stereoselective synthesis of bicyclo[3.2.0]heptanes via an anion radical [2+2] photocycloaddition of aryl bis-enone derivatives was investigated.
Sérgio Rossi +2 more
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Photochemical Intermolecular [3σ + 2σ]-Cycloaddition for the Construction of Aminobicyclo[3.1.1]heptanes. [PDF]
J Am Chem Soc, 2022 The development of synthetic strategies for the preparation of bioisosteric compounds is a demanding undertaking in medicinal chemistry. Numerous strategies have been developed for the synthesis of bicyclo[1.1.1]pentanes (BCPs), bridge-substituted BCPs ...
Zheng Y +6 more
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The attenuation of doxorubicin-induced testicular toxicity with improved testicular histoarchitecture of mice by the bioactive compounds in Solanum anomalum leaves: Experimental and computational studies [PDF]
Toxicology ReportsDoxorubicin, as an antibiotic causes toxicity in human tissues through the generation of oxidant species; however, Solanum anomalum (Solanaceae) is ethnopharmacologically and scientifically reported to possess antidotal activities.
Edet Effiong Asanga +7 more
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Synthesis of Heterocycle-Substituted Bicyclo[3.1.1]heptanes and Aza-bicyclo[3.1.1]heptanes via Photocatalytic Minisci Reaction. [PDF]
Org LettA route toward heterocycle-functionalized bicyclo[3.1.1]heptanes (BCHeps) and aza-bicyclo[3.1.1]heptanes (aza-BCHeps) has been developed, using mild, photocatalytic Minisci-like conditions to introduce various heterocycles at the bridgehead position from
Revie RI +4 more
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Enantioselective dearomative formal (3+3) cycloadditions of bicyclobutanes with aromatic azomethine imines: access to fused 2,3-diazabicyclo[3.1.1]heptanes. [PDF]
Chem SciAlthough cycloadditions of bicyclobutanes (BCBs) have emerged as a reliable approach for producing bicyclo[n.1.1]alkanes such as azabicyclo[3.1.1]heptanes (aza-BCHeps), serving as saturated bioisosteres of arenes, the catalytic asymmetric variant remains
Yang XC, Wu F, Wu WB, Zhang X, Feng JJ.
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Solvent effect on the morphology of the bee: structure observed by atomic force microscopy on bitumen sample [PDF]
Materials Research, 2014 The objective of this work was to characterize the asphaltic cement penetration grade 30/45 (CAP 30/45) based on the morphology of nanostructures called "bee" structure observed and its modification when the binder was diluted in heptanes or toluene. The
Bianca Pizzorno Backx +3 more
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Journal of the American Chemical Society, 2023 We report the use of photocatalysis for the homolytic ring-opening of carbonyl cyclopropanes. In contrast to previous studies, our approach does not require a metal cocatalyst or a strong reductant. The carbonyl cyclopropanes can be employed for both [2σ
Tin V T Nguyen +3 more
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Angewandte Chemie, 2023 A general approach to 3-azabicyclo[3.1.1]heptanes by reduction of spirocyclic oxetanyl nitriles was developed. The mechanism, scope, and scalability of this transformation were studied.
Dmitry Dibchak +9 more
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CHIMIA, 1976 A simple way to synthesize 7-phenyl-1-aza-bicyclo[2,2,1]heptanes out of 4-benzoyl-pyridines is described. The corresponding 3- benzoyl-pyridines did not yield the expected 7-phenyl-1-azabicyclo [3,1,1] heptanes.
A. Marxer
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