Results 161 to 170 of about 31,895 (247)

Simultaneous Activation of Bicyclobutanes and Indolyl Alcohols with HFIP: Access to Indole‐Fused Bicyclo[3.1.1]Heptanes

Angewandte Chemie - International Edition
The concept of strain release to unleash unique reactivity that drives a wide range of synthetically valuable transformations has long intrigued chemists.
Shiksha Deswal, Rohan Chandra Das, Deeptanu Sarkar, A. Biju   +3 more
exaly   +2 more sources

Selective [2σ + 2σ] Cycloaddition Enabled by Boronyl Radical Catalysis: Synthesis of Highly Substituted Bicyclo[3.1.1]heptanes.

Journal of the American Chemical Society, 2023
In contrast to the traditional and widely-used cycloaddition reactions involving at least a π bond component, a [2σ + 2σ] radical cycloaddition between bicyclo[1.1.0]butanes (BCBs) and cyclopropyl ketones has been developed to provide a modular, concise,
Tao Yu, Jinbo Yang, Zhijun Wang, Z. Ding, Ming Xu, J. Wen, Liang Xu, Pengfei Li   +7 more
semanticscholar   +1 more source

Photolysis of Heptanal

The Journal of Organic Chemistry, 2006
Photolysis of heptanal is investigated from an experimental and theoretical point of view. Photoexcited heptanal is believed to undergo rapid intersystem crossing to the triplet manifold and from there undergoes internal H-abstraction to form biradical intermediates.
Suzanne E, Paulson, De-Ling, Liu, Grazyna E, Orzechowska, Luis M, Campos, K N, Houk   +4 more
openaire   +2 more sources

Practical and Facile Access to Bicyclo[3.1.1]heptanes: Potent Bioisosteres of meta-Substituted Benzenes.

Journal of the American Chemical Society, 2022
There is increasing interest in replacement of the planar aromatic rings of drug candidates with three-dimensional caged scaffolds in order to improve the physical properties, but bioisosteres of meta-substituted benzenes have remained elusive.
Toranosuke Iida, Junichiro Kanazawa, Tadafumi Matsunaga, K. Miyamoto, Keiichi Hirano, M. Uchiyama   +5 more
semanticscholar   +1 more source

Intermolecular Crossed [2 + 2] Cycloaddition Promoted by Visible-Light Triplet Photosensitization: Expedient Access to Polysubstituted 2-Oxaspiro[3.3]heptanes.

Journal of the American Chemical Society, 2021
This paper describes an intermolecular cross-selective [2 + 2] photocycloaddition reaction of exocyclic arylidene oxetanes, azetidines, and cyclobutanes with simple electron-deficient alkenes.
Philip R. D. Murray, Willem M M Bussink, G. Davies, Farid W van der Mei, A. Antropow, Jacob T. Edwards, L. D’Agostino, J. Ellis, L. Hamann, Fedor Romanov-Michailidis, R. Knowles   +10 more
semanticscholar   +1 more source

Enantioselective Syntheses of 2-Azabicyclo[2.2.1]heptanes via Brønsted Acid Catalyzed Ring-Opening of meso-Epoxides.

Organic Letters, 2022
A chiral phosphoric acid-catalyzed ring-opening of meso-epoxides was developed. A range of 2-azabicyclo[2.2.1]heptanes were obtained in high yields with excellent enantioselectivities.
M. Cai, Jiao-li Ma, Qimin Wu, Aijun Lin, Hequan Yao   +4 more
semanticscholar   +1 more source

Silver-Enabled Cycloaddition of Bicyclobutanes with Isocyanides for the Synthesis of Polysubstituted 3-Azabicyclo[3.1.1]heptanes.

Angewandte Chemie
Synthesis of bicyclic scaffolds has emerged as an important research topic in modern drug development because they can serve as saturated bioisosters to enhance the physicochemical properties and metabolic profiles of drug candidates.
Yujie Liang, Ronewa Nematswerani, C. Daniliuc, F. Glorius   +3 more
semanticscholar   +1 more source

Eu(OTf)3-Catalyzed Formal Dipolar [4π + 2σ] Cycloaddition of Bicyclo-[1.1.0]butanes with Nitrones: Access to Polysubstituted 2-Oxa-3-azabicyclo[3.1.1]heptanes.

Angewandte Chemie
Herein, we have synthesized multifunctionalized 2-oxa-3-azabicyclo[3.1.1]heptanes, which are considered potential bioisosteres for meta-substituted arenes, through Eu(OTf)3-catalyzed formal dipolar [4π+2σ] cycloaddition of bicyclo[1.1.0]butanes with ...
Jian Zhang, Jia-Yi Su, Hanliang Zheng, Hao Li, Wei-Ping Deng   +4 more
semanticscholar   +1 more source

FeCl3-Catalyzed Intermolecular Formal [8π+2σ] Cycloaddition of Azaheptafulvene with Bicyclo[1.1.0]butanes for the Synthesis of Cycloheptatriene-Fused 2-Azabicyclo[3.1.1]heptanes.

Organic Letters
Higher-order cycloadditions are a simple and effective strategy for constructing significant medium-sized architectures. Azaheptafulvenes reacting with readily accessible bicyclo[1.1.0]butanes (BCBs) through FeCl3-promoted intermolecular formal [8π+2σ ...
Shijie Zhu, Jiaojiao Lei, Shengwen Yang, Zhifei Zhao, Ning Liu, Shi-Wu Li   +5 more
semanticscholar   +1 more source

Catalytic Asymmetric Construction of Chiral Polysubstituted 3-Azabicyclo[3.1.1]heptanes by Copper-Catalyzed Stereoselective Formal [4π+2σ] Cycloaddition.

Journal of the American Chemical Society
The direct construction of bioisosteric compounds enriched in Csp3 content represents an attractive and dependable approach to imbuing biologically active molecules with enhanced three-dimensional characteristics, finding wide utility across the ...
Xun Wang, Rongkai Gao, Xiaoxun Li
semanticscholar   +1 more source