Results 71 to 80 of about 90,036 (260)

‘Everywhere’s Burning’: Realising Climate Change and Activism Through Bushfires in Australian Young Adult Literature

International Journal of Young Adult Literature
As the climate crisis worsens, young people are becoming active ecocitizens and leaders in climate activism. YA literature serves as a safe space for readers to share traumatic experiences and see complex representations of climate anxiety and activism ...
Annika Herb
doaj   +1 more source

CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post‐traumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine osteoarthritis (OA) models that vary in severity of pathology and rate of progression to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source

Epigenetics as an answer to Darwin’s ‘special difficulty’

Frontiers in Genetics, 2014
Epigenetic modifications produce distinct phenotypes from the same genome through genome-wide transcriptional control. Recently, DNA methylation in honeybees and histone modifications in ants were found to assist the formation of caste phenotypes during ...
Brian R Herb
doaj   +1 more source

Efficacy and Safety of Nanoencapsulated Sirolimus Plus Pegadricase: Results From the Randomized, Placebo‐Controlled Phase 3 Trials

Arthritis &Rheumatology, EarlyView.
Objective DISSOLVE I and II examined the efficacy and safety of nanoencapsulated sirolimus (NAS) plus pegadricase (NASP) in patients with uncontrolled gout (UG). Methods In these double‐blind, placebo‐controlled Phase 3 trials of NASP, patients were randomized 1:1:1 to infusions of high‐dose (HD) or low‐dose (LD) NAS plus pegadricase (HD NASP, LD NASP,
Herbert S. B. Baraf, Puja P. Khanna, Milan Petronijevic, Mamuka Lortkipanidze, Anand Patel, Kwabena Ayesu, Michael H. Pillinger, Atul Singhal, Joanna Sobierska, Jacquie Christie, Peter Traber, Rehan Azeem, Wesley DeHaan, Hugues Santin‐Janin, Bhavisha Desai, Alan Kivitz   +15 more
wiley   +1 more source

Setting up mother–infant pair lactation studies with biobanking for research according to regulatory requirements

British Journal of Clinical Pharmacology, EarlyView.
Within the ConcePTION project we set out to design two mother–infant pair studies collecting breast milk and plasma from the mother and plasma from the infant (for metformin and prednisolone) in order to demonstrate the premises and conditions for investigating potential drug transfer in association with breastfeeding.
Mats Hansson, Ida Björkgren, Jenny Svedenkrans, Helena Backman, Jarl Hellman, Linda Englund‐Ögge, Mikaela Magnusson, Inger Lindström, Andrea Wutte, Erica Sundell, Pawel Baranczewski, Laura Shaughnessy   +11 more
wiley   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb–Drug Interaction Investigation

Biopharmaceutics &Drug Disposition, EarlyView.
Pharmacokinetic interactions between Echinacea and two antiviral drugs, favipiravir and atazanavir, were assessed in rats. The findings suggest that Echinacea does not significantly affect the pharmacokinetics of favipiravir and atazanavir. These results provide preliminary evidence that concurrent use of Echinacea with these antiviral drugs may be ...
Siva Nageswara Rao Gajula, Jeevan Sai Kallam, Aarika Kanukolanu, Ganesh Korada, Lakshmi Vineela Nalla   +4 more
wiley   +1 more source

Educational philosophising in the Everyday: UK immigrant mothers navigating identity and praxis during COVID‐19

British Educational Research Journal, EarlyView.
Abstract Debates surrounding motherhood have long centred on women's roles as carers. Although motherhood is now more widely recognised within feminist scholarship, it often remains conceptually separate from identities associated with formal educational discourse.
Lavinia Kamphausen, Aliya Khalid, Nadia Uddin‐Talukder, Uzma Dayan   +3 more
wiley   +1 more source

Differential Elevational Diversity Between Overstory and Understory in Tropical Forests

Biological Diversity, EarlyView.
Tropical forest overstory and understory exhibit contrasting elevational α‐diversity patterns (unimodal vs. bimodal). Community differentiation is driven by species turnover of dominant rather than rare species, highlighting the need for vertically stratified conservation across the full elevational gradient.
Xu Li, Zhipeng Li, Kunhong You, Yang Liu, Xialan Cheng, Han Sheng, Shaohang Huang, Chushu Meng, Shu‐Yi‐Dan Zhou, Zhiyang Lie, Juxiu Liu   +10 more
wiley   +1 more source

What drives animal responses to high severity fire? The role of functional traits

Biological Reviews, EarlyView.
ABSTRACT Fire regimes are changing worldwide, with increases in the frequency, extent, and severity of fires posing growing risks to biodiversity. Fire severity – the degree of habitat alteration following fire – strongly influences both immediate survival and long‐term recovery of fauna.
Grace A. Vielleux, Trent D. Penman, Victoria A. Reynolds, Matthew H. Swan   +3 more
wiley   +1 more source