Results 191 to 200 of about 146,599 (341)

Effect of Mild to Moderate Hepatic Impairment on Valemetostat Pharmacokinetics: An Open‐Label, Phase I Study

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Valemetostat tosylate (valemetostat) is a dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1, approved in Japan for the treatment of relapsed/refractory peripheral T‐cell lymphoma and adult T‐cell leukemia/lymphoma. This Phase I, open‐label study evaluated the pharmacokinetics and safety of a single 50‐mg oral dose of valemetostat in
Masaya Tachibana   +8 more
wiley   +1 more source

Herbal Medicine-Associated Lead Intoxication.

open access: bronze, 1997
Setsuo Hasegawa   +8 more
openalex   +2 more sources

International monitoring of adverse health effects associated with herbal medicines [PDF]

open access: bronze, 2000
Mohamed Farah   +4 more
openalex   +1 more source

Herbal Medicine Use Among Transplant Recipients in Saudi Arabia: Prevalence and Risk Awareness. [PDF]

open access: yesAnn Transplant
Almalki BA   +19 more
europepmc   +1 more source

Discovering Severe Adverse Reactions From Pharmacokinetic Drug–Drug Interactions Through Literature Analysis and Electronic Health Record Verification

open access: yesClinical Pharmacology &Therapeutics, Volume 117, Issue 4, Page 1078-1087, April 2025.
While drug–drug interactions (DDIs) and their pharmacokinetic (PK) mechanisms are well‐studied prior to drug approval, severe adverse drug reactions (SADRs) caused by DDIs often remain underrecognized due to limitations in pre‐marketing clinical trials.
Eugene Jeong, Yu Su, Lang Li, You Chen
wiley   +1 more source

Monoamine Oxidase Inhibitory Naphthoquinone and/or Naphthalene Dimers from Lemuni Hitam (Diospyros sp.), a Malaysian Herbal Medicine.

open access: bronze, 1999
Emi Okuyama   +7 more
openalex   +2 more sources

In vitro metabolism study of ADB‐P‐5Br‐INACA and ADB‐4en‐P‐5Br‐INACA using human hepatocytes, liver microsomes, and in‐house synthesized references

open access: yesDrug Testing and Analysis, Volume 17, Issue 5, Page 701-712, May 2025.
Analyzing hepatocytes and liver microsomes samples along with synthesized references. Complete structure elucidation of major metabolites was possible, and biomarkers for both ADB‐P‐5Br‐INACA and ADB‐4en‐P‐5Br‐INACA were suggested. Abstract Synthetic cannabinoids (SCs) remain a major public health concern, as they continuously are linked to severe ...
Tobias Rautio   +6 more
wiley   +1 more source

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