Results 281 to 290 of about 146,599 (341)

Clinical Assessment of the Drug–Drug Interaction Potential of Omaveloxolone in Healthy Adult Participants

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Omaveloxolone is approved in the United States and the European Union for the treatment of patients with Friedreich ataxia aged ≥16 years. It is mainly metabolized by cytochrome P450 (CYP) 3A4 in vitro. Two drug–drug interaction studies (NCT04008186 and NCT05909644) were performed to evaluate (1) the effect of drug‐metabolizing enzymes (DMEs ...
Hamim Zahir   +4 more
wiley   +1 more source

Effects of Hepatic or Renal Impairment on Pharmacokinetics of Fruquintinib

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Fruquintinib (FRUZAQLATM) is a highly selective tyrosine kinase inhibitor of all three vascular endothelial growth factor receptors (‐1, ‐2, and ‐3). Two Phase 1, open‐label, single‐dose studies investigated the impact of hepatic or renal impairment on the pharmacokinetics and tolerability of fruquintinib.
Martha Gonzalez   +8 more
wiley   +1 more source

Outcomes reporting in clinical trials of Chinese herbal medicine on ulcerative colitis: A systematic review. [PDF]

open access: yesJ Evid Based Med
Zhang X   +12 more
europepmc   +1 more source

A case of idiopathic mesenteric phlebosclerosis: Insight into pathogenesis of associated vascular calcification

open access: yesJournal of General and Family Medicine, EarlyView.
Abstract A 75‐year‐old woman had been taking a geniposide‐containing herbal medicine for 7 years and was admitted to our hospital for nausea, abdominal pain, and distention. CT revealed colonic wall thickening, whereas CS revealed a dark‐purple edematous mucosa. Furthermore, biopsy specimens revealed small vein hyalinization.
Kimitoshi Kubo, Noriko Kimura
wiley   +1 more source

Efficacy of Hongjing I granule, an herbal medicine, in patients with mild to moderate erectile dysfunction in a randomized controlled trial. [PDF]

open access: yesFront Pharmacol
Xu RN   +16 more
europepmc   +1 more source

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