Results 171 to 180 of about 269,395 (254)

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

Non-Polio Enterovirus A71 and D68 Infection of Human Neuromuscular Organoids Reveals Distinct Mechanisms of Neuromuscular Impairment. [PDF]

Viruses
Schotting AJ, García-Rodríguez I, Freeze E, Ambikan AT, Wagner M, Mioch M, Moffelein APYL, Jackson W, Pajkrt D, Wolthers KC, Sá RV, Sridhar A.   +11 more
europepmc   +1 more source

High‐throughput development and scale‐up of recombinant adeno‐associated virus 5 anion‐exchange chromatography for high‐purity capsid separation

Biotechnology Progress, EarlyView.
High‐throughput anion‐exchange chromatography process development enables scalable purification of high‐purity recombinant adeno‐associated virus capsids. Abstract Recombinant adeno‐associated virus (rAAV) production commonly yields a high proportion of empty and partially filled capsids, necessitating downstream purification to enrich full capsids ...
Kevin Vera, Ivan Gajic, Praveen Kusumanchi, Angela Andaluz, Gabrielle Dela Pena, Clifford A. Froelich, Elizabeth Higgins, Jennifer Johnston, Seyed Pouria Motevalian   +8 more
wiley   +1 more source

Chromosome-level genome assembly of Dynastes reidi reveals structural evolution of autosomes and the sex chromosomes in Hercules beetles. [PDF]

G3 (Bethesda)
Le MH, Proctor M, Huang JP.
europepmc   +1 more source

Small scale purification and biophysical characterization of haptoglobin derived from human Cohn fraction IV

Biotechnology Progress, EarlyView.
Abstract Haptoglobin (Hp) is a polymorphic acute phase α‐2 glycoprotein found in plasma that plays a critical role in binding, neutralizing, and removing cell‐free hemoglobin (Hb) from the circulation. Under clinical conditions characterized by high levels of hemolysis, such as in patients with sickle cell disease (SCD), large quantities of cell‐free ...
Shuwei Lu, Mohd Asim Khan, Pedro Cabrales, David C. Irwin, Paul W. Buehler, Andre F. Palmer   +5 more
wiley   +1 more source

Reply: Statistical Fragility and Methodological Constraints in Metabolomic Mediation of Air Pollution and Cardiovascular Risk. [PDF]

JACC Adv
Liu C, Chang HH, Jones D, Quyyumi A, Liang D.   +4 more
europepmc   +1 more source

Isoform Specificity of a Compound Targeting Actin Filaments Containing Tropomyosin Tpm1.8/1.9

Cytoskeleton, EarlyView.
ABSTRACT The unbranched actin filaments in mammalian cells are usually composed of co‐polymers of a specific tropomyosin isoform with actin. Genetic manipulation has revealed that the tropomyosins largely define the functional properties of actin filaments in an isoform‐specific, non‐redundant manner.
Jeff Hook, Edna C. Hardeman, Peter W. Gunning   +2 more
wiley   +1 more source

Endothelial VEGFR-2 Activation Precedes Severe Mucosal Injury in TNBS-Induced Colitis. [PDF]

Int J Mol Sci
Ceccariglia S, Sibilia D, Scattolini A, Saccone V, Parolini O, Armuzzi A, Papa A, Gasbarrini A, Pizzolante F.   +8 more
europepmc   +1 more source

Talin1 Adhesion Morphology and Colocalization With Tensin3 Are Largely Unaffected by Polyacrylamide Substrate Stiffness

Cytoskeleton, EarlyView.
ABSTRACT Cells sense the stiffness of their extracellular matrix (ECM) and adapt their behavior accordingly. We investigated how ECM stiffness affects the spatial organization of talin1, a key mechanosensitive focal adhesion protein. Using polyacrylamide (PA) hydrogels with tunable stiffnesses (0.2–188 kPa), we analyzed cell morphology, migration ...
Joanna Hajduk, Patrycja Twardawa, Sylwia Bobis‐Wozowicz, Marta Szewczyk, Zenon Rajfur, Zbigniew Baster   +5 more
wiley   +1 more source

Functional and Structural Determinants of Human Sperm Cryoresistance: Insights from Motility, Mitochondrial and Chromatin Integrity Analyses. [PDF]

Cells
Tvrdá E, Omolaoye TS, Ďuračka M, AlObeidli F, Du Plessis SS.   +4 more
europepmc   +1 more source