Results 111 to 120 of about 727,838 (288)
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
A Rare Case Report of Zinsser–Engman–Cole Syndrome: A Hereditary Cause of Aplastic Anemia
APIK Journal of Internal MedicineDyskeratosis congenita (DC), also known as Zinsser–Engman–Cole syndrome, is a rare cause of hereditary aplastic anemia. Here, we report a case of a 31-year-old male who presented with complaints of shortness of breath and recurrent episodes of fever for ...
Ch. Harshika, L. Sunil Kumar
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Editorial: Hereditary Breast and Ovarian Cancer: Current Concepts of Prevention and Treatment
Frontiers in Oncology, 2020 Anne Grabenstetter +2 more
doaj +1 more source
Familial aggregation of tonsillectomy in early childhood and adolescence
Clinical Epidemiology, 2018 Peter Bager, Giulia Corn, Jan Wohlfahrt, Heather A Boyd, Bjarke Feenstra, Mads Melbye Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark Background: The tonsils are immunological gatekeepers against ...
Bager P +5 more
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Case report: ZFYVE19 gene mutation is associated with familial cholestasis
Frontiers in MedicineThe etiology of cholestatic liver disease is complex, with clinical manifestations being nonspecific, and biochemical abnormalities mainly characterized by elevated alkaline phosphatase (ALP) and glutamyl transpeptidase (GGT). Due to the lack of specific
Mei-Yan Xue +8 more
doaj +1 more source