Results 161 to 170 of about 509,181 (309)

Beyond the variant: hereditary cancer awareness in the multi-omics era. [PDF]

Hereditas
Kazi JU, Massoumi R.
europepmc   +1 more source

Leber´s hereditary optic neuroretinopathy [PDF]

, 1993
Toyka, K., Schneider, C., Klopstock, Thomas, Janetzky, B., Seibel, P., Lindner, A., Trappe, J., Reichmann, Heinz   +7 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Support for Disclosure of Hereditary Tumor Risk to Children and Adolescents: A Scoping Review. [PDF]

Jpn J Nurs Sci
Sugima K, Arimori N, Uchimura M, Miyauchi A, Horiuchi S.   +4 more
europepmc   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Awareness, Attitudes, and Expectations of Indian Cancer Patients and Their Caregivers on Hereditary Cancers and Genetic Testing at a Tertiary Cancer Centre in India. [PDF]

J Genet Couns
Pathak RS, Angre A, Talker J, Sarin R.
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Clinical Utility of Germline Whole-Exome Sequencing Beyond Multigene Panels in Hereditary Cancer. [PDF]

Genes (Basel)
Dell'Elice A, Lombardi L, Anaclerio F, Palmarini C, Canale N, Secondi L, Stratta G, Vitali M, Tavoletta MS, Grossi S, Babore A, Milillo C, Dovizio M, Ballerini P, Gatta V, Stuppia L, Antonucci I.   +16 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

A Germline <i>BRCA2</i> Pathogenic Variant Identified by Multigene Panel Testing in Upper Tract Urothelial Carcinoma. [PDF]

IJU Case Rep
Matsuo K, Zennami K, Yoshida M, Hatakeyama M, Morikawa M, Hattori K, Akamatsu S.   +6 more
europepmc   +1 more source