Results 261 to 270 of about 200,644 (312)
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Current Opinion in Pediatrics, 2005
Major advances have been made in understanding the clinical signs and symptoms, the pathophysiology and the treatment of hereditary angioedema. This disease that often begins in childhood is caused by partial absence of the plasma protein C1-inhibitor.
openaire +4 more sources
Major advances have been made in understanding the clinical signs and symptoms, the pathophysiology and the treatment of hereditary angioedema. This disease that often begins in childhood is caused by partial absence of the plasma protein C1-inhibitor.
openaire +4 more sources
Annals of Emergency Medicine, 1988
Although the condition is rare, patients with hereditary angioedema often present because of abdominal pain or airway compromise. A 27-year-old woman presented to the emergency department in acute abdominal distress. Identification of the disease in this patient allowed for proper management and avoidance of invasive procedures.
G P, Moore, W T, Hurley, S A, Pace
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Although the condition is rare, patients with hereditary angioedema often present because of abdominal pain or airway compromise. A 27-year-old woman presented to the emergency department in acute abdominal distress. Identification of the disease in this patient allowed for proper management and avoidance of invasive procedures.
G P, Moore, W T, Hurley, S A, Pace
openaire +2 more sources
Guidelines for management of hereditary angioedema: What is new? What is missing?
Allergy and Asthma Proceedings, 2022Background: Hereditary angioedema is an autosomal dominant disease that presents with recurrent episodic swelling of the submucosal and/or subcutaneous tissues of the cutaneous, gastrointestinal, and respiratory systems.
C. Radojicic
semanticscholar +1 more source
Clinical reviews in allergy and immunology
Hereditary angioedema (HAE) has been recognized for almost 150 years. The newest form of HAE, where C1 inhibitor levels are normal (HAE-nC1INH), was first described in 2000.
Bruce L. Zuraw +34 more
semanticscholar +1 more source
Hereditary angioedema (HAE) has been recognized for almost 150 years. The newest form of HAE, where C1 inhibitor levels are normal (HAE-nC1INH), was first described in 2000.
Bruce L. Zuraw +34 more
semanticscholar +1 more source
CRISPR-Cas9 In Vivo Gene Editing of KLKB1 for Hereditary Angioedema.
New England Journal of MedicineBACKGROUND Hereditary angioedema is a rare genetic disease that leads to severe and unpredictable swelling attacks. NTLA-2002 is an in vivo gene-editing therapy based on clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated
Hilary Longhurst +22 more
semanticscholar +1 more source
Hereditary Angioedema and Pregnancy
Obstetric Anesthesia Digest, 2009Background: Hereditary angioedema (HAE) is an autosomal dominant disease caused by a quantitative or functional defect in C1‐esterase inhibitor (C1‐INH). Patients with this deficiency present with episodes of angioedema which can be life‐threatening. Studies examining HAE and pregnancy are scarce with little known about the interrelationship between ...
Niranthari, Chinniah +1 more
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Oral Sebetralstat for On-Demand Treatment of Hereditary Angioedema Attacks.
New England Journal of MedicineBACKGROUND Approved on-demand treatments for hereditary angioedema attacks need to be administered parenterally, a route of administration that is associated with delays in treatment or withholding of therapy.
Marc A. Riedl +30 more
semanticscholar +1 more source
CRISPR-Based Therapy for Hereditary Angioedema.
New England Journal of MedicineBACKGROUND Hereditary angioedema is a rare genetic disease characterized by severe and unpredictable swelling attacks. NTLA-2002 is an in vivo gene-editing therapy that is based on clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-
D. M. Cohn +16 more
semanticscholar +1 more source
Efficacy and Safety of Donidalorsen for Hereditary Angioedema.
New England Journal of MedicineBACKGROUND Hereditary angioedema is a rare disorder characterized by episodic, potentially life-threatening swelling caused by kallikrein-kinin dysregulation. Long-term prophylaxis can stabilize this system.
Marc A. Riedl +17 more
semanticscholar +1 more source
Hereditary angioedema: Epidemiology and burden of disease.
Allergy and Asthma Proceedings, 2020Hereditary angioedema (HAE) is a rare autosomal dominant genetic disorder characterized by swelling of subcutaneous, mucosal, and submucosal tissue without associated pruritus or wheals caused by a temporary localized increase in vascular permeability ...
W. Lumry, R. Settipane
semanticscholar +1 more source