Results 171 to 180 of about 91,474 (255)

Anatomically Guided Non-Viral CRISPR/Cas9 Delivery in the Eye: Overcoming Barriers for Precision Gene Therapy. [PDF]

Pharmaceutics
Hua Z, Shen Y, Zhou X.
europepmc   +1 more source

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Cranial Nerve Involvement With Diplopia as Presenting Feature of CMT1H Caused by Recurring FBLN5 Variant. [PDF]

J Peripher Nerv Syst
Koutsis G, Kontogeorgiou Z, Tzempetzis C, Ragazos N, Efthymiou E, Kartanou C, Koniari C, Giagkou N, Chatzistefanou K, Velonakis G, Karadima G, Zouvelou V.   +11 more
europepmc   +1 more source

Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound

Advanced Science, EarlyView.
In this study, Qiu et al. found that low‐intensity ultrasound can directly activate sparse ultrasound‐sensitive neurons (UNs) in the primary visual cortex (V1) of deafened mice. The proportion of these sparse UNs is pressure‐dependent. Furthermore, ultrasound modulates visual circuitry with distinct excitatory and inhibitory effects.
Jiaru He, Jiejun Zhu, Xinxin Wang, Zihao Chen, Jin Yang, Zhen Yuan, Hongzhi Xu, Lei Sun, Zhihai Qiu   +8 more
wiley   +1 more source

Leber Hereditary Optic Neuropathy-Associated Novel Mutation in <i>MT-RNR2</i> Gene: A Case Report. [PDF]

Case Rep Ophthalmol
KamaliZonouzi S, Micieli J.
europepmc   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

The eye-mind connection: a systematic review of retinal biomarkers and ocular signatures in major psychiatric disorders. [PDF]

Eur J Med Res
Motamedi R, Hayeri Mehrizi F, Zeinali Ali Abadi M, Mohagheghi M, Nourollahi Fomeshi F, Mousavikhah SE, Ghaffarzadeh A, Yaghmayee S, Arab Bafrani M, Sadat Rafiei SK, Shafiei D, Asadi Anar M, Khosravi F, Faizabadi S, Bozorgi M, Saien S.   +15 more
europepmc   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Simultaneous onset of visual dysfunction and cerebral infarction in a young patient with CADASIL: a case report. [PDF]

Front Med (Lausanne)
Liang G, Xu J, Wu Z.
europepmc   +1 more source

Neurodegenerative diseases in Latin American countries: a view from the III International Conference on Hereditary Ataxias [PDF]

, 2009
Parra, Mario
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