Results 91 to 100 of about 14,685,767 (350)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hereditary and environmental factors of the Five-Factor Model traits: A cross-cultural study

, 2020
Snežana Smederevac, Dušanka Mitrović, Selka Sadiković, Rainer Riemann, Denis Bratko, Mechthild Prinz, Zoran Budimlija   +6 more
openalex   +2 more sources

[Hereditary factors in tumors of the digestive system].

, 1996
Gastrointestinal tumours are an excellent model for the investigation of hereditary factors in cancer. Epidemiological studies on high risk population (China, Iran) evidenced a strong familiarity for esophageal cancer with up to 60% of the affected ...
PERCESEPE, Antonio, PONZ DE LEON, Maurizio   +1 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hereditary angioedema with normal C1 inhibitor and factor XII mutation: a series of 57 patients from the French National Center of Reference for Angioedema [PDF]

, 2016
Alban Deroux, Isabelle Boccon‐Gibod, Olivier Fain, P. Pralong, Yann Ollivier, Anne Pagnier, Kamel Djenouhat, A. Du‐Thanh, Anne Gompel, C. Faisant, David Launay, Laurence Bouillet   +11 more
openalex   +1 more source

Management of acute attacks of hereditary angioedema: potential role of icatibant

, 2010
Hilary J LonghurstDepartment of Immunology, Barts and The London NHS Trust, London, UKAbstract: Icatibant (Firazyr®) is a novel subcutaneous treatment recently licensed in the European Union for acute hereditary angioedema. Hereditary angioedema,
Hilary J Longhurst
core  

Estudi de les mutacions dels exons 2 i 4 del gen HFE en pacients amb porfiria cutània tarda esporàdica [PDF]

, 2006
[cat] La Porfíria Cutània Tarda (PCT) és una malaltia metabòlica que afecta a la pell i al fetge i que és desencadenada per la interacció de múltiples factors que inclouen l´herència, l´alcohol, el VHC, els estrògens i alguns agents tòxics, entre d ...
Toll Abelló, Agustí
core  

Prognostic factors for hereditary cancer distress six months after BRCA1/2 or HNPCC genetic susceptibility testing.

, 2007
Item does not contain fulltextThis study explored predictors for hereditary cancer distress six months after genetic susceptibility testing for a known familial BRCA1/2 or HNPCC related mutation, in order to gain insight into aspects relevant for the ...
Oostrom, I, Brocker-Vriends, AHJT, Seynaeve, C., Brocker-Vriends, A.H., Tibben, A., Sijmons, Rolf H., Brocker-Vriends, Annette H. J. T., van Oostrom, Iris, van Asperen, Christi J., Van Gool, Arthur R., van Asperen, CJ, Gool, A.R. van, Duivenvoorden, Hugo, Klijn, Jan G. M., Tibben, Aad, Sijmons, RH, Meijers-Heijboer, H., Seynaeve, Caroline, Meijers-Heijboer, Hanne, Asperen, C.J. van, Meijers-Heijboer, EJ, Klijn, J.G.M., Duivenvoorden, Hugo J., Klijn, Jan, Sijmons, R.H., Oostrom, I.I.H. van, Gool, AR, Duivenvoorden, H.J.   +27 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Structural and functional characterization of CSDA protein complexes involved in the modulation of fetal globin gene expression

, 2009
Impaired switching from fetal hemoglobin (HbF) to adult globin gene expression leads to hereditary persistence of fetal hemoglobin (HPFH) in adult life.
Gaudino, Sara
core