Results 51 to 60 of about 14,685,767 (350)

Hereditary Thrombophilic Factors in Stroke Due to Cerebral Infarct

, 2009
Background: The stroke is the third most common cause of all deaths. In new Studies, the importance of hereditary thrombophilic factors on stroke is emphasized.
Akyol, Ali, Kiylioglu, Nefati, Batun, Sabri, Bolaman, Zahit, Kadikoylu, Gurhan, Erturk, Ahmet, Ozkul, Ayca   +6 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reproductive factors in hereditary breast cancer

, 1999
BACKGROUND: An early age at menarche, a short menstrual cycle length, and a high age at first full term pregnancy or nulliparity are known risk factors for breast cancer.
Loman, Niklas,, Jernström, Helena, Borg, Åke,, Borg, Åke, Olsson, Håkan,, Johannsson, Oskar T, Jernström, Helena,, Lund University., Loman, Niklas, Olsson, Håkan   +9 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Hereditary non-polyposis colorectal carcinoma (HNPCC) : morphological and immunohistochemical studies

, 2005
Includes bibliographical references.Families with hereditary non-polyposis colorectal carcinoma (HNPCC) are not uncommon along the West-Coast of South Africa.
Holm, Hannes
core  

Never too old: Late-onset Leber Hereditary Optic Neuropathy

, 2018
Leber Hereditary Optic Neuropathy (LHON) is a maternally transmitted mitochondrial disease that primarily affects young adults in the second or third decade (typically between 15-25 years), with males affected approximately 2-20 times more often than ...
Kirsty A Lowe, Stephen J Vincent, Vincent, Stephen J., Monsour, Cindy S., Lowe, Kirsty A., Cindy S Monsour   +5 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

20 Discovery of Novel African American Genetic Risk Factors for Breast Cancer by Analyzing Whole Genome Sequencing Data of the Alabama Hereditary Cancer Cohort [PDF]

, 2023
Troy LoBue, Betsy Stallworth, Sheniqua R. Glover, Isaac McNeely, Nancy D. Merner   +4 more
openalex   +1 more source