Results 121 to 130 of about 8,566 (280)

Expression characteristics of dual‐specificity phosphatase 2 and hypoxia‐inducible factor‐1α in acute kidney injury and preliminary study of the effect of dual‐specificity phosphatase 2 on HK‐2 cells

open access: yesExperimental Physiology, EarlyView.
ABSTRACT Acute kidney injury (AKI) is a global health problem with significant long‐term harm if the prognosis is poor. Dual‐specificity phosphatase 2 (DUSP2) is involved in key regulatory pathways in several disease processes, but its function in renal pathophysiology is unclear.
Xueqian Chu   +8 more
wiley   +1 more source

Real‐world efficacy and toxicity of ipilimumab and nivolumab as a first‐line treatment for advanced renal cell carcinoma according to IMDC risk criteria—A multi‐center retrospective analysis on behalf of the GUARDIANS group

open access: yesInternational Journal of Cancer, Volume 158, Issue 9, Page 2440-2451, 1 May 2026.
What's new? The combination of ipilimumab and nivolumab as a first‐line treatment for advanced renal cell carcinoma has demonstrated durable response and tolerability in clinical trials. However, inclusion criteria for clinical studies are restrictive, and patients in the real‐world setting tend to have more comorbidities.
Hendrik Dinkel   +21 more
wiley   +1 more source

Protective Effect of LGG From Lophatherum Gracile Brongn. on Alcohol‐Injured HepG2 Cells and Exploration of Potential Mechanism

open access: yeseFood, Volume 7, Issue 2, April 2026.
LGG was separated from L. gracile and its hepatoprotective effect was investigated. LGG significantly reduced the mortality, ROS and MDA content in alcohol‐injured liver cells. LGG up‐regulated 156 mRNAs (63 miRNAs) and down‐regulated 1529 mRNAs (35 miRNAs).
Yi‐Long Ma   +9 more
wiley   +1 more source

Tryptophan‐Derived Microbial Metabolite Indole‐3‐Acetic Acid Ameliorates Periodontitis Through AhR/CYP1A1‐Mediated Macrophage Polarisation

open access: yesJournal of Clinical Periodontology, Volume 53, Issue 4, Page 644-655, April 2026.
ABSTRACT Aim To investigate the association between tryptophan‐derived microbial metabolites and periodontitis, and to assess whether the differential tryptophan metabolite indole‐3‐acetic acid (IAA) could ameliorate periodontitis and elucidate its potential mechanism.
Shuyu Cheng   +9 more
wiley   +1 more source

Glomerular Ultrastructural Findings Similar to Hereditary Nephritis in 4 English Cocker Spaniels [PDF]

open access: bronze, 1997
George E. Lees   +4 more
openalex   +1 more source

Sharing Is Caring?—Pathogens and Pathogen‐Specific Antibodies in Arctic Endemic Seal Species and the Newly Sympatric Harbor Seals in Kongsfjorden, Svalbard

open access: yesMarine Mammal Science, Volume 42, Issue 2, April 2026.
ABSTRACT Climate change associated transformations of Arctic marine ecosystems are having detrimental impacts on Arctic endemic marine mammals. However, warming conditions are providing new habitats for temperate marine mammals, some of which are expanding into Arctic regions, posing a threat of novel pathogen introduction and disease transmission.
Luca A. Schick   +11 more
wiley   +1 more source

Identifying High‐Impact Solutions to Address Racial and Ethnic Health Disparities in Lupus: A Consensus‐Based Approach

open access: yesArthritis Care &Research, Volume 78, Issue 3, Page 371-377, March 2026.
Objective We conducted formative research aimed at identifying solutions that address inequitable health outcomes in lupus due to adverse social determinants of health (SDoH). Methods We conducted a search for keywords, which provided insights into potential solutions and initiatives underway. An advisory panel of lupus experts iteratively reviewed the
Joy Buie   +11 more
wiley   +1 more source

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