Results 151 to 160 of about 744 (162)

Asymptomatic Carrier Neurologic Assessment: A Tool for Early Detection of Symptomatic Transition in Pathogenic TTR Gene Variant Carriers

European Journal of Neurology, Volume 33, Issue 9, September 2026.
There are no tools to support early detection of ATTRv signs/symptoms or to identify risk of transition to clinically detectable disease in carriers of pathogenic ATTRv variants. This retrospective cohort study describes the ACNA, a brief 23‐item assessment for use in routine clinical visits.
Isabel Conceição, Juan González‐Moreno, Andoni Echaniz‐Laguna, Kuangnan Xiong, Adam Castaño, Jonathan C. Fox, Julian D. Gillmore, Pablo Garcia‐Pavia, Mary M. Reilly   +8 more
wiley   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, Volume 293, Issue 18, Page 5600-5626, September 2026.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Hyperbaric Oxygen Therapy for Diabetic Foot Ulcers in Sub‐Saharan Africa: A Critical Review of Clinical Evidence, Health‐System Feasibility and Public Health Implications

International Wound Journal, Volume 23, Issue 9, September 2026.
ABSTRACT Diabetic foot ulcers are an important cause of morbidity, amputation, disability and healthcare expenditure in sub‐Saharan Africa, where limitations in preventive foot care, referral pathways, vascular services, multidisciplinary wound care and financial protection may contribute to poor outcomes.
Matthew Chibunna Igwe, Esther Ugo Alum, Alphonsus Ogbonna Ogbuabor, Yibala Ibor Oboma, Onyinyechi Bede‐Ojimadu, Charles Iyore Idehen   +5 more
wiley   +1 more source

Evidence Map Analysis on Randomized Controlled Trials: Chinese Patent Medicines and Classic Traditional Chinese Medicine Prescriptions

Journal of Evidence-Based Medicine, Volume 19, Issue 3, September 2026.
ABSTRACT Objectives To evaluate the status and methodological quality of randomized controlled trials published in 2024 on Chinese patent medicines and Classic Traditional Chinese Medicine Prescriptions, providing evidence for clinical practice and policy.
Xiaolei Wu, Yazi Zhang, Jinji Zhao, Haiyin Hu, Alice Josephine Fauci, Myeong Soo Lee, Zifan Sang, Danni Li, Ni Qin, Tianhui Sun, Jiaqi Yu, Menglong Shi, Boli Zhang, Junhua Zhang, Zhaochen Ji   +14 more
wiley   +1 more source

Duagnosis: Locating Clinical Uncertainty in the Diagnostic Framework

Journal of Evaluation in Clinical Practice, Volume 32, Issue 6, September 2026.
ABSTRACT Rationale, Aims and Objectives Clinical reasoning research has predominantly operated within a single epistemological system. The prevailing response to clinical uncertainty in primary care has been to cultivate tolerance, embrace ambiguity, or learn to navigate it: each treats uncertainty as inherent to the encounter.
Kosei Hanaoka, Daisuke Miyamori, Keiko Ogawa‐Ochiai   +2 more
wiley   +1 more source

Boy in the Barrel: Excruciating Paroxysmal Pain Disorder Associated With an SCN9A Gain‐of‐Function Variant

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT Background and Aims Gain‐of‐function variants in SCN9A, encoding the Nav1.7 sodium channel, cause inherited painful neuropathic disorders. We report a young man with severe childhood‐onset heat‐triggered paroxysmal pain, autonomic dysfunction, skeletal abnormalities, and a de novo SCN9A p.Ile234Thr variant, emphasizing the diagnostic and ...
Pedro Jose Tomaselli, Rodrigo Siqueira Soares Frezatti, Christopher J. Record, Maria Cristina Lopes Schiavoni, Natalia Dominik, Jana Vandrovcova, Mary M. Reilly, Wilson Marques Jr   +7 more
wiley   +1 more source

The Burden of Small Fiber Neuropathy: Changes in Pain, Costs, and Quality of Life Before and After Diagnosis

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT Background and Aims Small fiber neuropathy (SFN) is a peripheral neuropathy causing neuropathic pain, reduced quality of life (QoL), and high societal costs. Previous studies assessed these societal costs before a definitive diagnosis was established, leaving it unclear whether diagnostic confirmation affects costs, pain intensity, or QoL ...
Dennis Kool, Margot Geerts, Lloyd Brandts, Merel Kimman, Caroline M. L. Gorissen‐Brouwers, Catharina G. Faber, Ingemar S. J. Merkies, Janneke G. J. Hoeijmakers   +7 more
wiley   +1 more source

Neuropathy in Val122Ile Hereditary Transthyretin (ATTR) Amyloidosis: A Multicenter Retrospective Cohort Study

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT Background and Aims The Val122Ile ATTR Amyloidosis has traditionally been linked to cardiac manifestations. Recent studies suggest that neuropathy may be relevant. In this study, we characterized its peripheral nerve manifestations in depth. Methods This was a national, multicenter, observational, retrospective study.
Anna Paula Paranhos, Marcela Câmara Machado Costa, Carolina Lavigne Moreira, Diogo Fernandes dos Santos, Marcondes Cavalcante França, Renan Flavio de França Nunes, Osvaldo José Moreira do Nascimento, Jemima Araujo da Silva Batista, Eduardo Boiteux Uchôa Cavalcanti, Cleonisio Leite Rodrigues, Ândrea Virgínia Ferreira Chaves, Marcelo Soares Kerstenetzky, Lara Albuquerque de Brito, Carlo Domênico Marrone, Marcus Vinicius Magno Gonçalves, Pedro José Tomaselli, Wilson Marques   +16 more
wiley   +1 more source

Insights Into Self‐Care of Feet When Living With Diabetes: A Phenomenological Hermeneutic Interview Study

Journal of Clinical Nursing, Volume 35, Issue 9, Page 3912-3920, September 2026.
ABSTRACT Aim To describe how persons with diabetes experience learning about self‐care, with a particular focus on foot self‐care. Methods Narrative, semi‐structured interviews were conducted with persons diagnosed with Type 1 or Type 2 diabetes.
Kristofer Björk, Henrik Eriksson, Ulla Hellstrand Tang, Susanne Andersson   +3 more
wiley   +1 more source

Physiologically‐Guided Ultrafiltration: A Proposed Ultrasound Framework for Individualized Volume Removal During Hemodialysis

Nephrology, Volume 31, Issue 9, September 2026.
ABSTRACT Ultrafiltration during hemodialysis is the most hemodynamically stressful intervention dialysis patients endure, yet its prescription relies on interdialytic weight gain and clinical gestalt. Rates exceeding 13 mL/kg/h carry substantially higher cardiovascular mortality, and recurrent intradialytic hypotension drives myocardial stunning ...
Sharad Patel, Arwa Bootwala, Adam Green
wiley   +1 more source