Results 81 to 90 of about 744 (162)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Identification of a novel DNMT1 mutation in a Chinese patient with hereditary sensory and autonomic neuropathy type IE

BMC Neurology, 2018
Background DNA methyltransferase 1 (EC 2.1.1.37), encoded by DNMT1 gene, is one of key enzymes in maintaining DNA methylation patterns of the human genome.
Wenxia Zheng, Zhenxing Yan, Rongni He, Yaowei Huang, Aiqun Lin, Wei Huang, Yuying Su, Shaoyuan Li, Victor Wei Zhang, Huifang Xie   +9 more
doaj   +1 more source

A Case of Hereditary Sensory Neuropathy Type II with Acroosteolysis

, 1997
The hereditary sensory neuropathy is a very rare disease characterized by prominent sensory loss without corresponding motor involvement, but may be associated with autonomic features.
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Dietary melatonin and its benefits on cardiovascular disease

British Journal of Pharmacology, EarlyView.
Cardiovascular disease remains the leading cause of mortality globally, with a disproportionate burden in low‐ and middle‐income countries. Melatonin, a hormone primarily produced by the pineal gland, exhibits notable antioxidant, anti‐inflammatory and immunomodulatory properties that may confer cardiovascular benefits.
Karabo Tisane, Carmelita Abrahams, Sandrine Lecour   +2 more
wiley   +1 more source

Self-mutilating behavior in a 2-year-old girl unveiling the diagnosis of a rare entity – Midface toddler excoriation syndrome

Muller Journal of Medical Sciences and Research
Midface toddler excoriation syndrome (MiTES) is a less severe form of hereditary sensory-autonomic neuropathy Type VIII characterised by self-inflicted excoriations.
Fida Anjum, Malcolm Pinto, Abdul Khader Mohamed Ajmal, Amina Asfiya   +3 more
doaj   +1 more source

Hereditary sensory and autonomic neuropathy type IC accompanied by upper motor neuron abnormalities and type II juxtafoveal retinal telangiectasias

, 2019
Hereditary sensory and autonomic neuropathy type I (HSAN-1) is an autosomal dominant sensory neuropathy occurring secondary to mutations in the SPTLC1 and SPTLC2 genes.
Nicholson, Garth, Triplett, James, James Triplett, Garth Nicholson, Hornemann, Thorsten, Yiannikas, Con, Thorsten Hornemann, Carolyn Sue, Con Yiannikas, Sue, Carolyn   +9 more
core   +1 more source

The Variant p.(Arg183Trp) in SPTLC2 Causes Late-Onset Hereditary Sensory Neuropathy [PDF]

, 2016
Hereditary sensory and autonomic neuropathy 1 (HSAN1) is an autosomal dominant disorder that can be caused by variants in SPTLC1 or SPTLC2, encoding subunits of serine palmitoyl-CoA transferase.
Suriyanarayanan, Saranya, Tyynismaa, Henna, Toppila, Jussi, Schoen, Ulrike, Ylikallio, Emil, Walter, Maggie C, Schön, Ulrike, Rautenstrauss, Bernd, Walter, Maggie C., Palin, Eino, Hornemann, Thorsten, Wei, Yu, Abicht, Angela, Auranen, Mari, Shcherbii, Maria, Lohioja, Tarja, Paetau, Anders, Schlotter-Weigel, Beate   +17 more
core   +1 more source

Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic (CKLM) syndrome.
Virginia Anagnostopoulou, Christoforos K. Travlos, Lucas Lage Marinho, Thomas A. Mavrakanas, João Pedro Ferreira, Abhinav Sharma   +5 more
wiley   +1 more source

Genetic variants in DNMT1 and the risk of cardiac autonomic neuropathy in women with type 1 diabetes

Journal of Diabetes Investigation, 2019
Aims/Introduction Epigenetics participate in the pathogenesis of metabolic memory, a situation in which hyperglycemia exerts prolonged deleterious effects even after its normalization.
Daniele Pereira Santos‐Bezerra, Sharon Nina Admoni, Rosana Cristina Mori, Tatiana Souza Pelaes, Ricardo Vesoni Perez, Cleide Guimarães Machado, Maria Beatriz Monteiro, Maria Candida Parisi, Elizabeth Joao Pavin, Marcia Silva Queiroz, Marisa Passarelli, Ubiratan Fabres Machado, Maria Lucia Correa‐Giannella   +12 more
doaj   +1 more source

Determinant Factors of Self‐Care Deficit in People With Chronic Wounds: A Scoping Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aims To identify and synthesise the scientific evidence on determinants of self‐care deficits in people with chronic wounds. Design Scoping review based on the Joanna Briggs Institute guidelines. Methods This scoping review was conducted by a review team responsible for study screening, data extraction and synthesis.
Janislei Soares Dantas, Yan Lincoln Mamede Gomes, Ana Clara de Macedo Farias Ramos, Selene Cordeiro Vasconcelos, Maria Eliane Moreira Freire   +4 more
wiley   +1 more source