Results 41 to 50 of about 219,352 (339)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The allergic phenotype during the first 10 years of life in a prospective cohort

Immunity, Inflammation and Disease, 2019
Background Heredity and environmental parameters jointly affect allergy development. Here, we used a Swedish prospective cohort to study the influence of heredity and factors usually associated with allergic disease and the development of allergic ...
Sophia Björkander, Jenny Hallberg, Jan‐Olov Persson, Gunnar Lilja, Caroline Nilsson, Eva Sverremark‐Ekström   +5 more
doaj   +1 more source

HEREDITY [PDF]

American Journal of Psychiatry, 1901
Library's copy inscribed by author. ; "From the published transactions of the Medical Association of the State of Alabama." ; Title from cover. ; Mode of access: Internet.
openaire   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Genetic, epigenetic and exogenetic information [PDF]

, 2017
We describe an approach to measuring biological information where ‘information’ is understood in the sense found in Francis Crick’s foundational contributions to molecular biology.
Griffiths, Paul Edmund, Stotz, Karola
core  

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Tumor necrosis factor receptor-associated cycle syndrome: a case report and literature review

Frontiers in Pediatrics, 2023
Recurring episodes of fever characterize tumor necrosis factor receptor-associated periodic syndrome (TRAPS) which is autosomal dominant. The primary symptoms of patients with TRAPS include prolonged fever, abdominal pain, muscle pain, and skin rashes ...
Ziwei Li, Xiaoping Jing, Shuya Zhang, Tiantian Liu, Qingyin Guo   +4 more
doaj   +1 more source

Negative phenotypic and genetic associations between copulation duration and longevity in male seed beetles [PDF]

, 2009
Reproduction can be costly and is predicted to trade-off against other characters. However, while these trade-offs are well documented for females, there has been less focus on aspects of male reproduction.
AA Hoffmann, B Zwaan, C Mühlhäuser, CW Fox, D Houle, D J Hosken, D Reznick, DA Dewsbury, DA Roff, DA Roff, DJ Hodgson, DJ Hosken, DJ Hosken, DS Falconer, E A Brown, FJ Messina, G Arnqvist, GA Schwarzenbach, GJ Kenagy, HS Crudgington, IT MacBean, J Hunt, J Hunt, JS Kotiaho, L Gay, L Partridge, LW Simmons, LW Simmons, M Ackermann, M Edvardsson, M Edvardsson, M Gasser, M Lynch, M Tatar, MD Tuttle, ME Czesak, MH Gromko, MJG Gage, MJG Gage, MR Rose, MT Siva-Jothy, N Wedell, NG Prasad, OY Martin, OY Martin, P E Eady, P Eady, PE Eady, R Thornhill, R Vasudev, S Paukku, S Pitnick, S Wigby, S-B Horng, T Burk, T Chapman, T Clutton-Brock, T Miyatake, T Price, T Tregenza, TA Mousseau, UM Savalli, UM Savalli, UM Savalli, WA Becker, WA Van Voorhies, WG Hill, WJ Bailey, WU Blanckenhorn, Y Qi   +69 more
core   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source