Results 211 to 220 of about 36,434 (294)

Improving the In Silico Assessment of Proarrhythmia Risk by Combining hERG (Human Ether-à-go-go-Related Gene) Channel–Drug Binding Kinetics and Multichannel Pharmacology

Circulation: Arrhythmia and Electrophysiology, 2017
Zhihua Li, S. Dutta, Jiansong Sheng, Phu N. Tran, Wendy W Wu, Kelly C. Chang, T. Mdluli, D. Strauss, T. Colatsky   +8 more
semanticscholar   +1 more source

Models of hERG Block [PDF]

Biophysical Journal, 2018
Brandon Franks, Glenna C.L. Bett, Randall Rasmusson   +2 more
openaire   +1 more source

HERGAI: an artificial intelligence tool for structure-based prediction of hERG inhibitors. [PDF]

J Cheminform
Tran-Nguyen VK, Randriharimanamizara UF, Taboureau O.   +2 more
europepmc   +1 more source

A plethora of mechanisms in the HERG-related long QT syndrome Genetics meets electrophysiology [PDF]

, 1999
Dan M. Roden
openalex   +1 more source

Voltage sensor conformations induced by LQTS-associated mutations in hERG potassium channels. [PDF]

Nat Commun
Chan AN, Quach CD, Handlin LJ, Lessie EN, Tajkhorshid E, Dai G.   +5 more
europepmc   +1 more source

Novel Indirect AMP-Activated Protein Kinase Activators: Identification of a Second-Generation Clinical Candidate with Improved Physicochemical Properties and Reduced hERG Inhibitory Activity

, 2020
Kazuyuki Kuramoto, Yuki Sawada, Tomohiro Yamada, Takeyuki Nagashima, Kei Ohnuki, Takashi Shin   +5 more
openalex   +2 more sources

Age- and sex-dependent mRNA expression of KCNQ1 and HERG in patients with long QT syndrome type 1 and 2 [PDF]

, 2011
Ewa Moric‐Janiszewska, Joanna Głogowska‐Ligus, Monika Paul-Samojedny, Ludmiła Węglarz, Grażyna Markiewicz‐Łoskot, Lesław Szydłowski   +5 more
openalex   +1 more source

Harnessing AlphaFold to reveal hERG channel conformational state secrets. [PDF]

Elife
Ngo K, Yang PC, Yarov-Yarovoy V, Clancy CE, Vorobyov I.   +4 more
europepmc   +1 more source

Long QT Syndrome-associated Mutations in the Per-Arnt-Sim (PAS) Domain of HERG Potassium Channels Accelerate Channel Deactivation

, 1999
Jun Chen, Anrou Zou, Igor Splawski, Mark T. Keating, Michael C. Sanguinetti   +4 more
openalex   +1 more source

Reciprocal action of a synthetic estrogen and hERG blockers on the hERG channel

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2019
Shintaro Sugimoto, Fumiya Tamura, Nanami Iwasaki, Masaki Ieda, Kazuho Sakamoto, Junko Kurokawa   +5 more
openaire   +2 more sources