Results 11 to 20 of about 355,175 (361)
Partitioning heritability by functional annotation using genome-wide association summary statistics
Nature Genetics, 2015 Recent work has demonstrated that some functional categories of the genome contribute disproportionately to the heritability of complex diseases. Here we analyze a broad set of functional elements, including cell type–specific elements, to estimate their
Hilary K. Finucane +21 more
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Graph pangenome captures missing heritability and empowers tomato breeding
Nature, 2022 Missing heritability in genome-wide association studies defines a major problem in genetic analyses of complex biological traits1,2. The solution to this problem is to identify all causal genetic variants and to measure their individual contributions3,4.
Yao Zhou +21 more
semanticscholar +1 more source
Gut microbiome heritability is nearly universal but environmentally contingent
Science, 2021 Baboons inform on human gut microbiota Commensal bacteria are found throughout an organism, but it is not known whether associations between gut bacteria and their host are heritable. Grieneisen et al.
Laura E. Grieneisen +20 more
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Heritability and interindividual variability of regional structure-function coupling
Nature Communications, 2021 White matter structural connections are likely to support flow of functional activation or functional connectivity. While the relationship between structural and functional connectivity profiles, here called SC-FC coupling, has been studied on a whole ...
Zijin Gu +3 more
semanticscholar +1 more source
Statistical methods for SNP heritability estimation and partition: A review
Computational and Structural Biotechnology Journal, 2020 In GWAS studies, SNP heritability measures the proportion of phenotypic variance explained by all measured SNPs. Accurate estimation of SNP heritability can help us better understand the degree to which measured genetic variants influence phenotypes ...
Huanhuan Zhu, Xiang Zhou
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Frontiers in Neuroinformatics, 2019 Imaging genetic analyses use heritability calculations to measure the fraction of phenotypic variance attributable to additive genetic factors. We tested the agreement between heritability estimates provided by four methods that are used for heritability
Peter Kochunov +21 more
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Accurate Genomic Prediction Of Human Height [PDF]
, 2017 We construct genomic predictors for heritable and extremely complex human quantitative traits (height, heel bone density, and educational attainment) using modern methods in high dimensional statistics (i.e., machine learning).
Avery, Steven G. +5 more
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Estimates of the Heritability of Human Longevity Are Substantially Inflated due to Assortative Mating [PDF]
Genetics, 2018 Here, Ruby et al. analyze an unprecedented amount of public family tree data from Ancestry and determine that the heritability of human longevity was well below 10%, lower than the widely-held belief that lifespan...
J. Graham Ruby +13 more
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Aquaculture Reports, 2021 The occurrence of inbreeding over generations cannot be avoided in breeding practice because of limited effective population sizes, and inbreeding is expected to decrease the heritability within populations.
Jiafeng Fang, Ziqiang Han, Qi Li
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Genetic variability and correlation analysis of rice (Oryza sativa L.) inbred lines based on agro-morphological traits [PDF]
, 2016 In order to evaluate genetic variability of agro-morphological traits and also determine the correlation between grain yield with its components in rice lines, 17 recombinants inbred lines, their parents and a check variety were grown in research station
Audebert, Alain +4 more
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