Results 11 to 20 of about 91,892 (256)

Boosting heritability: estimating the genetic component of phenotypic variation with multiple sample splitting

BMC Bioinformatics, 2021
Background Heritability is a central measure in genetics quantifying how much of the variability observed in a trait is attributable to genetic differences.
The Tien Mai, Paul Turner, Jukka Corander   +2 more
doaj   +1 more source

Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits. [PDF]

PLoS Genetics, 2013
Important knowledge about the determinants of complex human phenotypes can be obtained from the estimation of heritability, the fraction of phenotypic variation in a population that is determined by genetic factors.
Noah Zaitlen, Peter Kraft, Nick Patterson, Bogdan Pasaniuc, Gaurav Bhatia, Samuela Pollack, Alkes L Price   +6 more
doaj   +1 more source

Heritability of endometriosis [PDF]

Fertility and Sterility, 2015
To estimate the relative contribution of genetic influences and prevalence on endometriosis.Analysis of self-reported data from a nationwide population-based twin registry.Not applicable.A total of 28,370 women, female monozygotic (MZ) or dizygotic (DZ) twins, who participated in either of two surveys (1998-2002 or 2005-2006).None.Self-reported ...
Rama, Saha, Hans Järnbert, Pettersson, Pia, Svedberg, Matts, Olovsson, Agneta, Bergqvist, Lena, Marions, Per, Tornvall, Ralf, Kuja-Halkola   +7 more
openaire   +2 more sources

Statistical methods for SNP heritability estimation and partition: A review

Computational and Structural Biotechnology Journal, 2020
In GWAS studies, SNP heritability measures the proportion of phenotypic variance explained by all measured SNPs. Accurate estimation of SNP heritability can help us better understand the degree to which measured genetic variants influence phenotypes ...
Huanhuan Zhu, Xiang Zhou
doaj   +1 more source

Homogenizing Estimates of Heritability Among SOLAR-Eclipse, OpenMx, APACE, and FPHI Software Packages in Neuroimaging Data

Frontiers in Neuroinformatics, 2019
Imaging genetic analyses use heritability calculations to measure the fraction of phenotypic variance attributable to additive genetic factors. We tested the agreement between heritability estimates provided by four methods that are used for heritability
Peter Kochunov, Binish Patel, Habib Ganjgahi, Brian Donohue, Meghann Ryan, Elliot L. Hong, Xu Chen, Bhim Adhikari, Neda Jahanshad, Paul M. Thompson, Dennis Van’t Ent, Anouk den Braber, Eco J. C. de Geus, Rachel M. Brouwer, Dorret I. Boomsma, Hilleke E. Hulshoff Pol, Greig I. de Zubicaray, Katie L. McMahon, Nicholas G. Martin, Margaret J. Wright, Margaret J. Wright, Thomas E. Nichols   +21 more
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Heritability of scoliosis [PDF]

European Spine Journal, 2011
To estimate the heritability of scoliosis in the Swedish Twin Registry.Self-reported data on scoliosis from 64,578 twins in the Swedish Twin Registry were analysed. Prevalence, pair- and probandwise concordances and tetrachoric correlations in mono- and dizygotic same-sex twins were calculated. The relative importance of genetic variance, i.e.
Anna, Grauers, Iffat, Rahman, Paul, Gerdhem   +2 more
openaire   +2 more sources

Effect of inbreeding on performance and genetic parameters of growth and survival traits in the Pacific oyster Crassostrea gigas at larval stage

Aquaculture Reports, 2021
The occurrence of inbreeding over generations cannot be avoided in breeding practice because of limited effective population sizes, and inbreeding is expected to decrease the heritability within populations.
Jiafeng Fang, Ziqiang Han, Qi Li
doaj   +1 more source

Heritability of ADHD

Pediatric Neurology Briefs, 2000
A twin study design was used to examine the the genetic validity of attention deficit hypoeractivity disorder (ADHD)-related phenotypes.
J Gordon Millichap
doaj   +1 more source

Spatially Dense 3D Facial Heritability and Modules of Co-heritability in a Father-Offspring Design

Frontiers in Genetics, 2018
Introduction: The human face is a complex trait displaying a strong genetic component as illustrated by various studies on facial heritability. Most of these start from sparse descriptions of facial shape using a limited set of landmarks.
Hanne Hoskens, Hanne Hoskens, Jiarui Li, Jiarui Li, Karlijne Indencleef, Karlijne Indencleef, Dorothy Gors, Dorothy Gors, Maarten H. D. Larmuseau, Stephen Richmond, Alexei I. Zhurov, Greet Hens, Hilde Peeters, Peter Claes, Peter Claes, Peter Claes   +15 more
doaj   +1 more source

Phenome-wide heritability analysis of the UK Biobank.

PLoS Genetics, 2017
Heritability estimation provides important information about the relative contribution of genetic and environmental factors to phenotypic variation, and provides an upper bound for the utility of genetic risk prediction models.
Tian Ge, Chia-Yen Chen, Benjamin M Neale, Mert R Sabuncu, Jordan W Smoller   +4 more
doaj   +1 more source