Results 11 to 20 of about 152,085 (301)

On Negative Heritability and Negative Estimates of Heritability [PDF]

Genetics, 2017
Abstract We consider the problem of interpreting negative maximum likelihood estimates of heritability that sometimes arise from popular statistical models of additive genetic variation. These may result from random noise acting on estimates of genuinely positive heritability, but we argue that they may also arise from ...
Steinsaltz, David, Dahl, Andy, Wachter, Kenneth W.   +2 more
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BMI heritability and its relationship with puberty in 6 – 18-year-old twins

Zhongguo gonggong weisheng, 2023
ObjectiveTo analyze the heritability of body mass index (BMI) and the impact of puberty on the heritability among twins aged 6 – 18 years in Shandong province.
Tingting GUO, Yunjie BAI, Aiping FAN
doaj   +1 more source

Boosting heritability: estimating the genetic component of phenotypic variation with multiple sample splitting

BMC Bioinformatics, 2021
Background Heritability is a central measure in genetics quantifying how much of the variability observed in a trait is attributable to genetic differences.
The Tien Mai, Paul Turner, Jukka Corander   +2 more
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Heritability of endometriosis [PDF]

Fertility and Sterility, 2015
To estimate the relative contribution of genetic influences and prevalence on endometriosis.Analysis of self-reported data from a nationwide population-based twin registry.Not applicable.A total of 28,370 women, female monozygotic (MZ) or dizygotic (DZ) twins, who participated in either of two surveys (1998-2002 or 2005-2006).None.Self-reported ...
Rama, Saha, Hans Järnbert, Pettersson, Pia, Svedberg, Matts, Olovsson, Agneta, Bergqvist, Lena, Marions, Per, Tornvall, Ralf, Kuja-Halkola   +7 more
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Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits. [PDF]

PLoS Genetics, 2013
Important knowledge about the determinants of complex human phenotypes can be obtained from the estimation of heritability, the fraction of phenotypic variation in a population that is determined by genetic factors.
Noah Zaitlen, Peter Kraft, Nick Patterson, Bogdan Pasaniuc, Gaurav Bhatia, Samuela Pollack, Alkes L Price   +6 more
doaj   +1 more source

Improved heritability estimation from genome-wide SNPs [PDF]

, 2012
Narrow-sense heritability (h(2)) is an important genetic parameter that quantifies the proportion of phenotypic variance in a trait attributable to the additive genetic variation generated by all causal variants.
Johnson, Michael R., Balding, DJ, Hemani, G, Hemani, Gibran, Balding, David J., Speed, D, Johnson, MR, Speed, Doug   +7 more
core   +1 more source

Homogenizing Estimates of Heritability Among SOLAR-Eclipse, OpenMx, APACE, and FPHI Software Packages in Neuroimaging Data

Frontiers in Neuroinformatics, 2019
Imaging genetic analyses use heritability calculations to measure the fraction of phenotypic variance attributable to additive genetic factors. We tested the agreement between heritability estimates provided by four methods that are used for heritability
Peter Kochunov, Binish Patel, Habib Ganjgahi, Brian Donohue, Meghann Ryan, Elliot L. Hong, Xu Chen, Bhim Adhikari, Neda Jahanshad, Paul M. Thompson, Dennis Van’t Ent, Anouk den Braber, Eco J. C. de Geus, Rachel M. Brouwer, Dorret I. Boomsma, Hilleke E. Hulshoff Pol, Greig I. de Zubicaray, Katie L. McMahon, Nicholas G. Martin, Margaret J. Wright, Margaret J. Wright, Thomas E. Nichols   +21 more
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Statistical methods for SNP heritability estimation and partition: A review

Computational and Structural Biotechnology Journal, 2020
In GWAS studies, SNP heritability measures the proportion of phenotypic variance explained by all measured SNPs. Accurate estimation of SNP heritability can help us better understand the degree to which measured genetic variants influence phenotypes ...
Huanhuan Zhu, Xiang Zhou
doaj   +1 more source

Heritability of variation in glycaemic response to metformin:a genome-wide complex trait analysis [PDF]

, 2014
Background: Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable.
Ahlqvist, Emma,, Deshmukh, Harshal, Pearson, Ewan R., Deshmukh, H, Colhoun, Helen M, Morris, Andrew D., Morris, Andrew D, Groop, Leif,, Colhoun, HM, McCarthy, Mark I, Zhou, K, Palmer, Colin N A, Yang, J, Palmer, Colin N.A.; id_orcid, Zuydam, NV, Groop, L, Sham, Pak C, McCarthy, Mark, Spencer, Chris C, Donnelly, Lousie, Palmer, Colin N. A., Spencer, Chris C., Zhou, KX, Yang, Jian, Spencer, CC, Lund University., Palmer, CN, Donnelly, Louise, Li, M, McCarthy, MI, Van Zuydam, Natalie, Palmer, CNA, Zhou, Kaixin, Spencer, Chris, Pearson, Ewan R.; id_orcid, McCarthy, ML, Donnelly, L, Van Zuydam, N, Li, Miaoxin, Morris, AD, Groop, Leif, Sham, PC, McCarthy, Mark I., Ahlqvist, E, Groop, Lief, Pearson, Ewan R, Pearson, ER, Colhoun, Helen M., Sham, Pak C., Ahlqvist, Emma   +49 more
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The heritability of attractiveness [PDF]

Current Biology, 2007
SummarySexual selection is responsible for the evolution of numerous conspicuous and extravagant displays observed in nature — from cricket choruses to peacock's tails. A key assumption of many models of sexual selection is that attractive males father attractive sons1.
Taylor, Michelle L., Wedell, Nina, Hosken, David J.   +2 more
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