Results 191 to 200 of about 251,536 (320)

Targeted Next‐Generation Sequencing of the Leptin‐Melanocortin Pathway in Severe Obesity

Obesity, EarlyView.
ABSTRACT Objective Pathogenic variants in five established leptin‐melanocortin pathway genes (LEP, LEPR, MC4R, PCSK1, POMC) are associated with severe early‐onset obesity and are targets for emerging treatments. However, these variants are rare in these patients, suggesting the involvement of additional genes interacting with this pathway. Methods Next‐
Nathan Faccioli, Chrisitne Poitou, Mathieu Georget, Françoise Bertin, Ahlam Azar‐Kolakez, Claire Carette, Pauline Faucher, Blandine Gatta‐Cherifi, Julie Gonneau‐Lejeune, Agnès Linglart, Karine Clément, Johanne Le Beyec‐Le Bihan, Béatrice Dubern   +12 more
wiley   +1 more source

Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls [PDF]

, 2018
Agrawal, Arpana, et al,
core   +1 more source

Heritability of face shape in twins: a preliminary study using 3D stereophotogrammetry and geometric morphometrics

, 2013
Seth M. Weinberg, Trish E. Parsons, Mary L. Marazita, Brion S. Maher   +3 more
openalex   +2 more sources

Heritability of Atherosclerosis [PDF]

American Journal of Hypertension, 2007
openaire   +2 more sources

Not just ‘super‐predators': human behaviour shapes wildlife behavioural responses across avoidance, tolerance and attraction

Oikos, EarlyView.
Humans are thought to have a disproportionately negative impact on wildlife and are viewed by some as the ultimate ‘super predator'. This view implies that wild animals perceive humans primarily as predators. However, a growing body of evidence shows that wildlife can have remarkable tolerance for, or even attraction to, humans.
Friederike Zenth, Daniel T. Blumstein, Luca Corlatti, Mengxi Kou, Sebastian Schwegmann, Farina Sooth, Ilse Storch, Manisha Bhardwaj   +7 more
wiley   +1 more source

Attenuation of HIV severity by slightly deleterious mutations can explain the long-term trajectory of virulence evolution. [PDF]

PLoS Comput Biol
Longley H, Fraser C, Wymant C, Lythgoe K.   +3 more
europepmc   +1 more source

Resource limitation and competition shape reproductive allocation and synchrony

Oikos, EarlyView.
The dynamics of reproductive allocation (RA) in herbaceous plant communities, particularly in response to varying environmental conditions such as drought stress and competitive interactions, remain underexplored. This study aims to fill this gap by hypothesising that both belowground resource limitation and the presence of dominant species ...
Jan Douda, Jana Doudová, Alena Havrdová   +2 more
wiley   +1 more source

Heritability and shared environmental effects of brain diseases in 12,040 extended families. [PDF]

NPJ Dement
Dijkstra JIR, Hulsman M, Waterink L, Holstege H, Teunissen CE, Christiaansen WFL, de Jong BA, Kochunov P, Donohue B, Zwan MD, den Braber A, Vermunt L, van der Lee SJ.   +12 more
europepmc   +1 more source

Evidence for Oxidative Activation of c-Myc–Dependent Nuclear Signaling in Human Coronary Smooth Muscle Cells and in Early Lesions of Watanabe Heritable Hyperlipidemic Rabbits [PDF]

, 2000
Filomena de Nigris, Tammam Youssef, SilviaAnna Ciafré, Flavia Franconi, Vittorio Anania, Gianluigi Condorelli, Wulf Palinski, Claudio Napoli   +7 more
openalex   +1 more source

Colours of urban selection: carotenoid‐based signals reveal divergent urban/rural evolutionary trajectories in two closely related passerines

Oikos, EarlyView.
Urbanisation is a major driver of environmental change, reshaping ecological and evolutionary processes. Urban‐driven phenotypic differences are increasingly documented, but the underlying role of selection is still understudied. One pattern is the consistent reduction of carotenoid‐based plumage pigmentation in city birds.
Nicolas Bekka, Simon Agostini, Samuel Perret, Clotilde Biard   +3 more
wiley   +1 more source