Results 51 to 60 of about 251,536 (320)
PLoS Genetics, 2013 The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to quantify heritability attributable to all interrogated variants. We have quantified
Lea K Davis +130 more
doaj +1 more source
Journal of Animal Reproduction and Biotechnology, 2016 Growth traits, such as body weight, directly influence productivity and economic efficiency in the swine industry. In this study, we estimate heritability for body weight traits usinginformation from pedigree and genome-wide single nucleotide ...
Hee-Bok Park +11 more
doaj +1 more source
Genotypic variation of dormancy in wheat (Triticum aestivum L.) : a thesis presented in partial fulfilment of the requirements for the degree of Master of Agricultural Science, Department of Plant Science, Massey University, Palmerston North, New Zealand [PDF]
, 1996 Embryo dormancy and α - amylase dormancy are desirable in wheat to minimise pre-harvest sprouting damage. The current work focuses on the embryo and graincoat colour.
Zvomuya, Norman
core
Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou +12 more
wiley +1 more source
Direct Estimates of the Genomic Contributions to Blood Pressure Heritability within a Population-Based Cohort (ARIC). [PDF]
PLoS ONE, 2015 Blood pressure (BP) is a heritable trait with multiple environmental and genetic contributions, with current heritability estimates from twin and family studies being ~ 40%.
Elias Salfati +3 more
doaj +1 more source
Lobular Difference in Heritability of Brain Atrophy among Elderly Japanese: A Twin Study
Medicina, 2022 Background and Objectives: Brain atrophy is related to cognitive decline. However, the heritability of brain atrophy has not been fully investigated in the Eastern Asian population.
Soichiro Saeki +7 more
doaj +1 more source
Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies [PDF]
, 2019 Objective: Tourette’s syndrome is polygenic and highly heritable. Genome-wide association study (GWAS) approaches are useful for interrogating the genetic architecture and determinants of Tourette’s syndrome and other tic disorders. The authors conducted
Gilles de la Tourette GWAS Replication Initiative +4 more
core +1 more source
Arthritis Care &Research, Accepted Article.Background Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of urate (FEUA) also modulates this response and relates to oxypurinol concentrations. We further evaluated its potential influence
Pascal Richette +13 more
wiley +1 more source
Frontiers in Genetics, 2020 Genome-Wide Association Studies (GWAS) explain only a small fraction of heritability for most complex human phenotypes. Genomic heritability estimates the variance explained by the SNPs on the whole genome using mixed models and accounts for the many ...
Arthur Frouin +6 more
doaj +1 more source
Relative abundance data can misrepresent heritability of the microbiome
Microbiome, 2023 Background Host genetics can shape microbiome composition, but to what extent it does, remains unclear. Like any other complex trait, this important question can be addressed by estimating the heritability (h 2 ) of the microbiome—the proportion of ...
Marjolein Bruijning +5 more
doaj +1 more source