Results 51 to 60 of about 236,259 (268)

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Heritability estimates of body size in fetal life and early childhood.

PLoS ONE, 2012
BackgroundThe objective was to estimate the heritability for height and weight during fetal life and early childhood in two independent studies, one including parent and singleton offsprings and one of mono- and dizygotic twins.MethodsThis study was ...
Dennis O Mook-Kanamori, Catharina E M van Beijsterveldt, Eric A P Steegers, Yurii S Aulchenko, Hein Raat, Albert Hofman, Paul H Eilers, Dorret I Boomsma, Vincent W V Jaddoe   +8 more
doaj   +1 more source

Exploring the Link Between Additive Heritability and Prediction Accuracy From a Ridge Regression Perspective

Frontiers in Genetics, 2020
Genome-Wide Association Studies (GWAS) explain only a small fraction of heritability for most complex human phenotypes. Genomic heritability estimates the variance explained by the SNPs on the whole genome using mixed models and accounts for the many ...
Arthur Frouin, Claire Dandine-Roulland, Morgane Pierre-Jean, Jean-François Deleuze, Jean-François Deleuze, Christophe Ambroise, Edith Le Floch   +6 more
doaj   +1 more source

Heritability of geographic range sizes revisited : a reply to Hunt et al. [PDF]

, 2005
Hunt et al.(2005) revisit the issue of range size heritability following our recent article on this topic (Webb and Gaston 2003). In that article, we showed that the range sizes of closely related species tend to be highly dissimilar and argued that this
Gaston, K.J., Webb, T.J.
core  

Negative phenotypic and genetic associations between copulation duration and longevity in male seed beetles [PDF]

, 2009
Reproduction can be costly and is predicted to trade-off against other characters. However, while these trade-offs are well documented for females, there has been less focus on aspects of male reproduction.
AA Hoffmann, B Zwaan, C Mühlhäuser, CW Fox, D Houle, D J Hosken, D Reznick, DA Dewsbury, DA Roff, DA Roff, DJ Hodgson, DJ Hosken, DJ Hosken, DS Falconer, E A Brown, FJ Messina, G Arnqvist, GA Schwarzenbach, GJ Kenagy, HS Crudgington, IT MacBean, J Hunt, J Hunt, JS Kotiaho, L Gay, L Partridge, LW Simmons, LW Simmons, M Ackermann, M Edvardsson, M Edvardsson, M Gasser, M Lynch, M Tatar, MD Tuttle, ME Czesak, MH Gromko, MJG Gage, MJG Gage, MR Rose, MT Siva-Jothy, N Wedell, NG Prasad, OY Martin, OY Martin, P E Eady, P Eady, PE Eady, R Thornhill, R Vasudev, S Paukku, S Pitnick, S Wigby, S-B Horng, T Burk, T Chapman, T Clutton-Brock, T Miyatake, T Price, T Tregenza, TA Mousseau, UM Savalli, UM Savalli, UM Savalli, WA Becker, WA Van Voorhies, WG Hill, WJ Bailey, WU Blanckenhorn, Y Qi   +69 more
core   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

Estimation of heritability and genetic advance for various metric traits in seven F2 populations of bread wheat (Triticum aestivum L.) [PDF]

Journal of Agricultural Sciences (Belgrade), 2016
Heritability estimates provide information about the traits that are transmitted from parents to their offsprings and it has a crucial role in selection criteria to improve grain yield.
Saleem Babar, Khan Abdus Salam, Shahzad Muhammad Talha, Ijaz Fahid   +3 more
doaj   +1 more source

Improving genetic risk prediction by leveraging pleiotropy

, 2013
An important task of human genetics studies is to accurately predict disease risks in individuals based on genetic markers, which allows for identifying individuals at high disease risks, and facilitating their disease treatment and prevention.
Gelernter, Joel, Li, Cong, Yang, Can, Zhao, Hongyu   +3 more
core   +1 more source

WUSCHEL Transcription Factor: From Stem Cell Maintenance to Crop Improvement

Advanced Science, EarlyView.
This review synthesizes emerging insights into WUSCHEL (WUS) as a central regulator of plant stem cell fate beyond Arabidopsis, highlighting its roles in regeneration, somatic embryogenesis (SE), and stress adaptation across crops. It explores how WUS‐centered regulatory networks, genome editing, and AI‐guided strategies can be leveraged for precise ...
Zishan Ahmad, Muthusamy Ramakrishnan, Rajeev K. Varshney, Anwar Shahzad, Shamsur Rehman, Bijaya Pant, Qiang Wei   +6 more
wiley   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source