Results 11 to 20 of about 953 (153)

Pediatric Pulmonary Hypertension is Associated With Increased Circulating Levels of BMP 7 and CHIP. [PDF]

Pulm Circ
ABSTRACT Pulmonary arterial endothelial and smooth muscle cell homeostasis is regulated through the bone morphogenetic protein (BMP) and transforming growth factor beta (TGF‐β) receptor pathways. Pathway imbalance results in pulmonary hypertension (PH). Each pathway has ligands and modulators influencing this balance.
Kirkpatrick EC, Handler S, Liegl M, Pan AY, Konduri GG, Gudausky TM, Afolayan AJ.   +6 more
europepmc   +2 more sources

Filgotinib Is an Effective and Safe Treatment Option for Difficult-To-Treat Ulcerative Colitis: Real-World Evidence of the Dutch Initiative on Crohn and Colitis (ICC) Registry. [PDF]

United European Gastroenterol J
ABSTRACT Background Filgotinib is a preferential Janus kinase 1 (JAK‐1) inhibitor registered for the treatment of ulcerative colitis (UC). Real‐world effectiveness of filgotinib, especially for difficult‐to‐treat (DTT, failure of ≥ 2 prior advanced therapies) patients, has been scarcely reported.
Naber MR, van der Meulen AE, Voorneveld PW, Veltkamp SHC, van Bodegraven AA, Bodelier A, Mujagic Z, Pierik M, Verleye LMM, Duijvestein M, Bouwknegt DG, Visschedijk MC, Srivastava N, West RL, Oldenburg B, Löwenberg M, van Schaik FDM, Dutch ICC Registry.   +17 more
europepmc   +2 more sources

Selective Fetoscopic Laser Photocoagulation of Placental Anastomoses Leads to Early Reduction of Cardiovascular Burden in the Twin-Twin Transfusion Syndrome. [PDF]

Prenat Diagn
ABSTRACT Objective Cardiovascular disturbances are common in twin‐twin transfusion syndrome (TTTS). However, the rate of improvement in cardiovascular burden in response to selective fetoscopic laser photocoagulation (SFLP) is not well known. Method Fetal echocardiograms were performed prior to and 1 week following SFLP.
Chaszczewski KJ, Perelman S, Falkensammer CB, Szwast A, Pang C, Tian Z, Gebb J, Moldenhauer J, Khalek N, Rychik J.   +9 more
europepmc   +2 more sources

Effects of Arterial Carbon Dioxide Tension on Cerebral and Somatic Regional Tissue Oxygenation and Blood Flow in Neonates After the Norwood Procedure With Deep Hypothermic Cardiopulmonary Bypass

Frontiers in Pediatrics, 2022
Neonates undergoing the Norwood procedure for hypoplastic left heart syndrome are at higher risk of impaired systemic oxygen delivery with resultant brain, kidney, and intestinal ischemic injury, shock, and death.
George M. Hoffman, George M. Hoffman, George M. Hoffman, George M. Hoffman, John P. Scott, John P. Scott, John P. Scott, John P. Scott, Eckehard A. Stuth, Eckehard A. Stuth   +9 more
doaj   +1 more source

Pulmonary Vascular Sequelae of Palliated Single Ventricle Circulation: Arteriovenous Malformations and Aortopulmonary Collaterals

Journal of Cardiovascular Development and Disease, 2022
Children and adults with single ventricle congenital heart disease (CHD) develop many sequelae during staged surgical palliation. Universal pulmonary vascular sequelae in this patient population include two inter-related but distinct complications ...
Andrew D. Spearman, Salil Ginde
doaj   +1 more source

Significance of α-Myosin Heavy Chain (MYH6) Variants in Hypoplastic Left Heart Syndrome and Related Cardiovascular Diseases

Journal of Cardiovascular Development and Disease, 2022
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with complex genetic inheritance. HLHS segregates with other left ventricular outflow tract (LVOT) malformations in families, and can present as either an isolated ...
Melissa Anfinson, Robert H. Fitts, John W. Lough, Jeanne M. James, Pippa M. Simpson, Stephanie S. Handler, Michael E. Mitchell, Aoy Tomita-Mitchell   +7 more
doaj   +1 more source

Evaluating threshold for donor fraction cell-free DNA using clinically available assay for rejection in pediatric and adult heart transplantation. [PDF]

Pediatr Transplant
Pediatric patients with rejection show higher levels of circulating df‐cfDNA compared to adults. The study supports using this cfDNA assay and specific cut points in pediatric and adult heart transplant patients with acceptable performance. Abstract Background The aims of the study were to assess the performance of a clinically available cell‐free DNA (
Deshpande SR, Zangwill SD, Richmond ME, Kindel SJ, Schroder JN, Gaglianello N, Bichell DP, Wigger MA, Knecht KR, Thrush PT, Mahle WT, North PE, Simpson PM, Zhang L, Dasgupta M, Tomita-Mitchell A, Mitchell ME.   +16 more
europepmc   +2 more sources

The association between cardiac magnetic resonance-derived aortic stiffness parameters and aortic dilation in young adults with bicuspid aortic valve: With and without coarctation of aorta

American Heart Journal Plus, 2022
Background: Bicuspid aortic valve (BAV) is associated with progressive aortic dilation. Studies in aortopathies have shown a correlation between increased aortic stiffness and aortic dilation.
Vasutakarn Chongthammakun, Amy Y. Pan, Michael G. Earing, Abdulla A. Damluji, Benjamin H. Goot, Joseph R. Cava, Jennifer F. Gerardin   +6 more
doaj   +1 more source

A Pilot Study Characterizing Flow Patterns in the Thoracic Aorta of Patients With Connective Tissue Disease: Comparison to Age- and Gender-Matched Controls via Fluid Structure Interaction

Frontiers in Pediatrics, 2022
Prior computational and imaging studies described changes in flow patterns for patients with Marfan syndrome, but studies are lacking for related populations.
Joseph A. Camarda, Ronak J. Dholakia, Hongfeng Wang, Margaret M. Samyn, Margaret M. Samyn, Joseph R. Cava, John F. LaDisa, John F. LaDisa, John F. LaDisa   +8 more
doaj   +1 more source

Therapeutic drug monitoring of methotrexate in patients with Crohn's disease

Alimentary Pharmacology &Therapeutics, Volume 58, Issue 11-12, Page 1151-1162, December 2023., 2023
Prospective cohort of patients with Crohn's disease starting methotrexate subcutaneously with therapeutic drug monitoring. Summary Background Therapeutic drug monitoring (TDM) has the potential to improve efficacy and diminish side effects. Measuring methotrexate‐polyglutamate (MTX‐PG) in erythrocytes might enable TDM for methotrexate in patients with ...
Maartje M. van de Meeberg, Herma H. Fidder, Bas Oldenburg, Janani Sundaresan, Eduard A. Struys, Nahid S. M. Montazeri, Wout G. N. Mares, Nofel Mahmmod, Dirk P. van Asseldonk, Maurice W. M. D. Lutgens, Johan P. Kuyvenhoven, Svend T. Rietdijk, Loes H. C. Nissen, Parweez Koehestanie, Nanne K. H. de Boer, Robert de Jonge, Gerd Bouma, Maja Bulatović Ćalasan, the Dutch Initiative on Crohn and Colitis (ICC), Fiona van Schaik, Inge van der Horst, Ruby Meiland, Marthe François‐Verweij, Alette Sijbring, Roeland Zoutendijk, Abdul Al‐toma, Thomas Boerlage, Martien van Wenum, Peter van der Schaar, Esmerij P. M. van Zanden, Dominique A. D. Bierens‐Peters, Maartje Lubsen, Line Meinsma‐Span, Margien L. Seinen, Jeroen Jansen, Pieter Scholten, Anneke de Schrijver, Tessa Römkens, Koen van Hee, Jochim ter Haar‐Sive droste, Ellen Rijsdijk, Kim van Boxtel, Merel Tielemans   +42 more
wiley   +1 more source