Results 251 to 260 of about 1,048,251 (344)

Chondrodystrophic Dogs as a Preclinical Large Animal Model of Discogenic Back Pain

open access: yesJOR SPINE, Volume 8, Issue 3, September 2025.
This study aims to validate an underutilized canine preclinical model of discogenic back pain model by deep phenotyping several structural and pain associated outcomes with novel findings in the areas of RNA sequencing and whole patch clamp of canine dorsal root ganglion neurons.
Mary K. Heimann   +18 more
wiley   +1 more source

Mechanistic Interactions Driving Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration: A Multi‐Axial Perspective of Mechanical, Immune, and Metabolic Pathways

open access: yesJOR SPINE, Volume 8, Issue 3, September 2025.
The senescence of NPCs is at the heart of the pathogenesis of intervertebral disc degeneration (IVDD), which causes low back discomfort. ABSTRACT Background The senescence of nucleus pulposus cells (NPCs) at the heart of the pathogenesis of intervertebral disc degeneration (IVDD), which causes low back pain.
Yunbo Yang   +3 more
wiley   +1 more source

Development and Validation of a Machine Learning‐Based Online Prognostic Model for Cervical Spondylosis Patients After Anterior Cervical Discectomy and Fusion: A Multicenter Study

open access: yesJOR SPINE, Volume 8, Issue 3, September 2025.
This was a multi‐center, retrospective, and prospective study based on multiple machine learning algorithms. This online predictive tool offers a robust framework for personalized postoperative management in CS patients, potentially improving clinical outcomes.
Sitan Feng   +12 more
wiley   +1 more source

Laparoscopic Versus Robotic Ventral Hernia Repair - An ACHQC Database 5-Year Analysis. [PDF]

open access: yesJ Abdom Wall Surg
Lima DL   +6 more
europepmc   +1 more source

Animal Models of Disc Degeneration Using Puncture Injury: A 20 Year Perspective

open access: yesJOR SPINE, Volume 8, Issue 3, September 2025.
This review of surgically induced IVD puncture injury animal models presents an evolution over decades to include many variations simulating distinct clinical phenotypes of IVDD, and recommends reporting a common set of injury features to facilitate cross‐study comparison.
Charu Jain   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy