Results 1 to 10 of about 64,605 (278)

Pharmacokinetic Correlates of the Effects of a Heroin Vaccine on Heroin Self-Administration in Rats

PLoS ONE, 2014
The purpose of this study was to evaluate the effects of a morphine-conjugate vaccine (M-KLH) on the acquisition, maintenance, and reinstatement of heroin self-administration (HSA) in rats, and on heroin and metabolite distribution during heroin ...
Michael D Raleigh, Paul R Pentel, Mark G Lesage   +2 more
exaly   +2 more sources

The association between chronic heroin smoking and chronic obstructive pulmonary disease

Journal of Pharmacy and Bioallied Sciences, 2021
Introduction: Little is known about the correlation between chronic obstructive pulmonary disease (COPD) and heroin smoking. Heroin smoking is a recent underinvestigated problem.
Ahmad Naoras Bitar, Amer Hayat Khan, Syed Azhar Syed Sulaiman, Irfhan Ali Bin Hyder Ali, Irfanullah Khan   +4 more
doaj   +1 more source

Natural Polyphenols—Resveratrol, Quercetin, Magnolol, and β-Catechin—Block Certain Aspects of Heroin Addiction and Modulate Striatal IL-6 and TNF-α

Toxics, 2023
We have examined the effects of four different polyphenols in attenuating heroin addiction using a conditioned place preference (CPP) paradigm. Adult male Sprague Dawley rats received heroin (alternating with saline) in escalating doses starting from 10 ...
Shaimaa ElShebiney, Rania Elgohary, Marwa El-Shamarka, Noha Mowaad, Osama A. Abulseoud   +4 more
doaj   +1 more source

Inhibition of Glycogen Synthase Kinase 3β Activity in the Basolateral Amygdala Disrupts Reconsolidation and Attenuates Heroin Relapse

Frontiers in Molecular Neuroscience, 2022
Exposure to a heroin-associated conditioned stimulus can reactivate drug reward memory, trigger drug cravings, and induce relapse in heroin addicts. The amygdala, a brain region related to emotions and motivation, is involved in processing rewarding ...
Yuanyang Xie, Yuanyang Xie, Yingfan Zhang, Ting Hu, Ting Hu, Zijin Zhao, Zijin Zhao, Qing Liu, Qing Liu, Haoyu Li, Haoyu Li   +10 more
doaj   +1 more source

Heroin pipe distribution to reduce high-risk drug consumption behaviors among people who use heroin: a pilot quasi-experimental study

Harm Reduction Journal, 2022
Background Heroin pipe distribution may encourage people who use heroin (PWUH) to transition from injecting to smoking heroin, reducing harms associated with injection drug use.
Thomas Fitzpatrick, Vanessa M. McMahan, Noah D. Frank, Sara N. Glick, Lauren R. Violette, Shantel Davis, Shilo Jama   +6 more
doaj   +1 more source

Hostility, compassion and role reversal in West Virginia’s long opioid overdose emergency

Harm Reduction Journal, 2020
Background West Virginia is a largely rural state with strong ties of kinship, mutual systems of support and charitable giving. At the same time, wealth inequalities are extreme and the state’s drug overdose fatality rate stands above all others in the ...
Jeff Ondocsin, Sarah G. Mars, Mary Howe, Daniel Ciccarone   +3 more
doaj   +1 more source

Cognitive Enhancer Donepezil Attenuates Heroin-Seeking Behavior Induced by Cues in Rats

Journal of Integrative Neuroscience, 2023
Purpose: Opioid use disorder is a significant global problem. Chronic heroin use is associated with impairment of cognitive function and conscious control ability.
Disen Mei, Fangmin Wang, Bo Yuan, Miaojun Lai, Yiying Zhou, Wei Cui, Huifen Liu, Wenhua Zhou   +7 more
doaj   +1 more source

Complex Interactions Between Sex and Stress on Heroin Seeking

Frontiers in Neuroscience, 2021
Rationale: Stress plays a dual role in substance use disorders as a precursor to drug intake and a relapse precipitant. With heroin use at epidemic proportions in the United States, understanding interactions between stress disorders and opioid use ...
Jordan S. Carter, Angela M. Kearns, Carmela M. Reichel   +2 more
doaj   +1 more source

Upregulation of SOCS-3 and PIAS-3 impairs IL-12-mediated interferon-gamma response in CD56 T cells in HCV-infected heroin users. [PDF]

PLoS ONE, 2010
CD56(+) T cells are abundant in liver and play an important role in host innate immunity against viral infections, including hepatitis C virus (HCV) infection, a common infection among heroin abusers. We thus investigated the in vivo impact of heroin use
Li Ye, Xu Wang, David S Metzger, Eric Riedel, Luis J Montaner, Wenzhe Ho   +5 more
doaj   +1 more source

Toots, tastes and tester shots: user accounts of drug sampling methods for gauging heroin potency

Harm Reduction Journal, 2018
Background Internationally, overdose is the primary cause of death among people injecting drugs. However, since 2001, heroin-related overdose deaths in the United States (US) have risen sixfold, paralleled by a rise in the death rate attributed to ...
Sarah G. Mars, Jeff Ondocsin, Daniel Ciccarone   +2 more
doaj   +1 more source