Results 91 to 100 of about 586,499 (386)

Investigation Into the Dynamics of the Cupula in the Vestibular Organ of Adult Zebrafish Using Metabolic Glycoengineering

Angewandte Chemie, EarlyView.
The cupula is a membrane within the vestibular organ that senses rotatory accelerations of the head. Metabolic glycoengineering in combination with bioorthogonal labeling demonstrates that in adult zebrafish – being a model for the human inner ear – this membrane is constantly renewed.
Hans Scherer, Andrea Jüngst, Verena F. Schöwe, Anne‐Katrin Gronewald, Valentin Wittmann   +4 more
wiley   +2 more sources

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

CONVULSIVE DISORDER IN CHILDREN: THE ROLE OF HERPES VIRUS INFECTIONS

Детские инфекции (Москва), 2015
Convulsive disorder frequently poses a great danger. The authors distinguish three groups of children who most often have convulsions. Those are «febrile» convulsions, convulsions that accomapny neuroinfections and epilepsy.
L. V. Vashura, M. S. Savenkova, N. N. Zavadenko, I. E. Koltunov, N. V. Carazhas, T. N. Rybalkina, M. Yu. Kalugina, A. V. Bullih   +7 more
doaj   +1 more source

Functional Neuroimaging in Psychiatry—Aiding in Diagnosis and Guiding Treatment. What the American Psychiatric Association Does Not Know

Frontiers in Psychiatry, 2020
While early efforts in psychiatry were focused on uncovering the neurobiological basis of psychiatric symptoms, they made little progress due to limited ability to observe the living brain. Today, we know a great deal about the workings of the brain; yet,
Theodore A. Henderson, Theodore A. Henderson, Theodore A. Henderson, Theodore A. Henderson, Muriel J. van Lierop, Muriel J. van Lierop, Mary McLean, Mary McLean, John Michael Uszler, John Michael Uszler, John Michael Uszler, John F. Thornton, John F. Thornton, Yin-Hui Siow, Yin-Hui Siow, Dan G. Pavel, Dan G. Pavel, Joe Cardaci, Joe Cardaci, Joe Cardaci, Joe Cardaci, Phil Cohen, Phil Cohen, Phil Cohen   +23 more
doaj   +1 more source

Clinical features of varicella-zoster virus infection [PDF]

, 2018
Varicella-zoster virus (VZV) is a pathogenic human herpes virus that causes varicella (chickenpox) as a primary infection, following which it becomes latent in peripheral ganglia.
Gershon, Anne A., Kennedy, Peter G.E.
core   +1 more source

EGR Proteins Mediate Interferon‐Independent Anti‐HSV‐1 Responses Through Viral and Host Targets

Advanced Science, EarlyView.
Early antiviral responses are typically mediated by interferons. However, during HSV‐1 infection, host early growth response (Egr) genes, which are not interferon‐stimulated genes, are quickly induced by viral protein ICP0. EGR proteins, in turn, suppress viral lytic infection by activating viral latency‐associated (LAT) and host immune regulatory ...
Shuaishuai Wang, Fujun Hou, Xunuo Jin, Yuhang Xiang, Dongli Pan   +4 more
wiley   +1 more source

Sexually transmitted infections, the silent partner in HIV-infected women in Zimbabwe

Southern African Journal of HIV Medicine, 2019
Background: Coinfection rates of HIV and sexually transmitted infections (STIs) are not widely reported in Zimbabwe and no local guidelines regarding the screening of STIs in people living with HIV exist.
Sara Lowe, Tinashe Mudzviti, Ardele Mandiriri, Tinei Shamu, Petronella Mudhokwani, Cleophas Chimbetete, Ruedi Luethy, Margaret Pascoe   +7 more
doaj   +1 more source

Pregnancy and contraceptive use among women participating in an HIV prevention trial in Tanzania. [PDF]

, 2012
OBJECTIVES: Information on pregnancy rates and factors associated with pregnancy and contraceptive use is important for clinical trials in women in sub-Saharan Africa where withdrawal of investigational products may be required in the event of pregnancy ...
Baisley, Kathy, Changalucha, John, Hayes, Richard J, Odutola, Aderonke, Ross, David A, Rusizoka, Mary, Tanton, Clare, Watson-Jones, Deborah, Weiss, Helen A   +8 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

The seroprevalence and salivary shedding of herpesviruses in Behçet's syndrome and recurrent aphthous stomatitis

Journal of Oral Microbiology, 2015
Background: Behçet's syndrome (BS) is one of the multisystemic diseases that presents with oral ulceration and several other systemic manifestations including genital ulceration, folliculitis, erythema nodosum-like lesions, uveitis, and arthropathy ...
Noha Seoudi, Lesley A. Bergmeier, Eleni Hagi-Pavli, David Bibby, Farida Fortune   +4 more
doaj   +1 more source